Neuroethological studies of fear, anxiety, and risky decision-making in rodents and humans.
Neuroethological studies of fear, anxiety, and risky decision-making in rodents and humans.
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DOI：
10.1016/j.cobeha.2015.06.005
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发表时间：
2015-10
影响因子：
5
通讯作者：
Kim JJ
中科院分区：
文献类型：
--
作者：
Mobbs D;Kim JJ
猎物无情地面临着一系列生存问题需要解决。一个持久的问题是捕食，猎物的答案依赖于其生命过程中培养的行为和后代遗传的防御反应之间复杂的相互作用。为了理解对类似威胁的近似神经反应，情感神经科学家青睐于控制良好的联想学习范式，但研究人员现在正在创造半现实的环境，以模拟猎物在现实世界中的选择，来检验决策和逃跑计算的动态流程。在动物行为学和行为生态学领域的研究背景下，我们回顾了啮齿动物和人类神经科学的一些最新文献，并讨论了这些研究如何有潜力为健康和病理恐惧和焦虑的行为表达、计算和神经回路提供新的见解。
Prey are relentlessly faced with a series of survival problems to solve. One enduring problem is predation, where the prey’s answers rely on the complex interaction between actions cultivated during its life course and defense reactions passed down by descendants. To understand the proximate neural responses to analogous threats, affective neuroscientists have favored well-controlled associative learning paradigms, yet researchers are now creating semi-realistic environments that examine the dynamic flow of decision-making and escape calculations that mimic the prey’s real world choices. In the context of research from the field of ethology and behavioral ecology, we review some of the recent literature in rodent and human neuroscience and discuss how these studies have the potential to provide new insights into the behavioral expression, computations, and the neural circuits that underlie healthy and pathological fear and anxiety.