Influence of gene action across different time scales on behavior
Influence of gene action across different time scales on behavior
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DOI：
10.1126/science.1069911
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发表时间：
2002-04-26
期刊：
影响因子：
56.9
通讯作者：
Robinson, GE
中科院分区：
文献类型：
--
作者：
Ben-Shahar, Y;Robichon, A;Robinson, GE
基因可以以不同的方式影响自然行为变异。等位基因变异导致不同的行为表型，而基因表达的变化可以影响不同年龄的行为起始。我们发现，蜜蜂从蜂巢工作到觅食的年龄相关转变与觅食（for）基因表达的增加有关，该基因编码鸟苷3 '，5'-单磷酸（cGMP）依赖性蛋白激酶（PKG）。cGMP处理提高PKG活性，并引起觅食行为。先前的研究表明PKG表达的等位基因差异导致两种果蝇觅食变体。因此，同一个基因可以对一种行为产生不同类型的影响。
Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging (for) gene, which encodes a guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior.