Nickel-Catalyzed Direct Carboxylation of Olefins with CO2: One-Pot Synthesis of α,β-Unsaturated Carboxylic Acid Salts
Nickel-Catalyzed Direct Carboxylation of Olefins with CO2: One-Pot Synthesis of α,β-Unsaturated Carboxylic Acid Salts
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DOI：
10.1002/chem.201405528
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发表时间：
2014-12-15
影响因子：
4.3
通讯作者：
Limbach, Michael
中科院分区：
文献类型：
--
作者：
Huguet, Nuria;Jevtovikj, Ivana;Limbach, Michael
以廉价易得的碳-1结构单元二氧化碳（CO2）为原料，在碱的存在下，实现了镍催化的烯烃直接羧化反应。一锅法反应允许直接和选择性地合成广泛的α，β-不饱和羧酸酯（TON>100，TOF高达6 h（-1），TON=转换数，TOF=转换频率）。因此，可以在一个步骤中由乙烯、CO2和钠盐合成丙烯酸钠。丙烯酸酯是工业上重要的产品，其合成迄今需要多个步骤。
The nickel-catalyzed direct carboxylation of alkenes with the cheap and abundantly available C-1 building block carbon dioxide (CO2) in the presence of a base has been achieved. The one-pot reaction allows for the direct and selective synthesis of a wide range of alpha,beta-unsaturated carboxylates (TON>100, TOF up to 6 h(-1), TON=turnover number, TOF=turnover frequency). Thus, it is possible, in one step, to synthesize sodium acrylate from ethylene, CO2, and a sodium salt. Acrylates are industrially important products, the synthesis of which has hitherto required multiple steps.