Sub-processes of motor learning revealed by a robotic manipulandum for rodents
Sub-processes of motor learning revealed by a robotic manipulandum for rodents
复制标题
DOI：
10.1016/j.bbr.2014.10.047
复制
发表时间：
2015-02-01
影响因子：
2.7
通讯作者：
Hosp, J. A.
中科院分区：
文献类型：
--
作者：
Lambercy, O.;Schubring-Giese, M.;Hosp, J. A.
啮齿动物模型被广泛用于研究运动学习引起的神经变化。通常，用于这一目的的运动学习任务的行为读数仅限于对性能的二进制测量(即“成功”动作与“失败”动作)。因此，啮齿动物研究对人类研究中获得的概念的可分配性--意味着构成运动学习的不同内部模型--仍然有限。为了解决这个问题，我们最近推出了一个为大鼠设计的三自由度机器人平台(ETH-Pattus)，它结合了准确的行为读数(以运动学的形式)和对大脑中与学习相关的变化进行侵入性评估的可能性(例如，通过在急性切片准备中执行免疫组织化学或电生理学)。在这里，我们通过建立两个技能程度不同的前肢到达范式来验证该平台作为研究运动学习的工具。这两种情况可以根据它们的时间模式和表现水平进行精确的区分。基于行为数据，我们假设存在几个有助于运动学习的子过程。这些与在人类或灵长类动物身上获得的概念有密切的相似之处。(C)2014爱思唯尔B.V.保留所有权利。
Rodent models are widely used to investigate neural changes in response to motor learning. Usually, the behavioral readout of motor learning tasks used for this purpose is restricted to a binary measure of performance (i.e. "successful" movement vs. "failure"). Thus, the assignability of research in rodents to concepts gained in human research - implying diverse internal models that constitute motor learning - is still limited. To solve this problem, we recently introduced a three-degree-of-freedom robotic platform designed for rats (the ETH-Pattus) that combines an accurate behavioral readout (in the form of kinematics) with the possibility to invasively assess learning related changes within the brain (e.g. by performing immunohistochemistry or electrophysiology in acute slice preparations).Here, we validate this platform as a tool to study motor learning by establishing two forelimb-reaching paradigms that differ in degree of skill. Both conditions can be precisely differentiated in terms of their temporal pattern and performance levels. Based on behavioral data, we hypothesize the presence of several sub-processes contributing to motor learning. These share close similarities with concepts gained in humans or primates. (C) 2014 Elsevier B.V. All rights reserved.