Apparent diffusion coefficients and T2 relaxation time measurements to evaluate disc degeneration - A quantitative MR study of young patients with previous vertebral fracture
Apparent diffusion coefficients and T2 relaxation time measurements to evaluate disc degeneration - A quantitative MR study of young patients with previous vertebral fracture
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DOI：
10.1080/028418501127347241
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发表时间：
2001-11-01
期刊：
影响因子：
1.3
通讯作者：
Tervonen, O
中科院分区：
文献类型：
--
作者：
Kerttula, L;Kurunlahti, M;Tervonen, O
目的：评估表观扩散系数（ADC）测量对评价椎间盘退变过程的适用性，并将结果与退变和正常椎间盘的T2弛豫时间测量结果进行比较。材料和方法：14名年轻患者（8.8-20.8岁）至少1年前患有椎骨压缩性骨折，在三个正交方向上进行MR扩散成像和T2弛豫时间测量。结果：退变椎间盘的ADC（x）和ADC（y）值较健康对照组明显降低，而正常椎间盘的ADC（x）和ADC（y）值较正常对照组明显降低。退变椎间盘的z方向ADC值与对照组无显著差异。T2弛豫时间较短，在退化的椎间盘的患者相比，对照组的值。在这两个值的最大变化，观察到在退变的椎间盘，其次是椎间盘与正常信号强度相邻的原发性创伤面积和继发性创伤area.Conclusion：我们建议，ADC值下降反映了失去了完整性的椎间盘。MR的ADC值可以敏感地反映椎间盘的早期退变。
Purpose: To assess the suitability of apparent diffusion coefficient (ADC) measurements to evaluate degeneration processes of the vertebral disc and to compare the results with T2 relaxation time measurements in both degenerated and normal intervertebral discs.Material and Methods: Fourteen young patients (8.8-20.8 years old) who had had a vertebral compression fracture at least 1 year earlier, underwent MR studies with diffusion imaging in three orthogonal directions and T2 relaxation time measurements. ADC values and T2 relaxation times of both degenerated and normal intervertebral discs were compared to the values of 20 healthy young asymptomatic control subjects.Results: In the degenerated discs of patients, the ADC(x) and ADC(y) values were decreased compared to earlier determined values of healthy controls. ADC values in the z-direction in degenerated discs did not differ significantly from the values of controls. T2 relaxation times were shorter in the degenerated discs of patients compared to the values of controls. The greatest changes in both these values were observed in degenerated discs followed by discs with normal signal intensity adjacent to primary trauma area and secondary trauma area.Conclusion: We suggest that decreased ADC values reflect the lost integrity of the intervertebral disc. ADC measurements at MR may prove sensitive depicting of early degenerative changes in vertebral discs.