GLUT-1 expression and response to chemoradiotherapy in rectal cancer
GLUT-1 expression and response to chemoradiotherapy in rectal cancer
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DOI：
10.1002/ijc.24693
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发表时间：
2009-12-15
影响因子：
6.4
通讯作者：
Kay, Elaine W.
中科院分区：
文献类型：
--
作者：
Brophy, Sarah;Sheehan, Katherine M.;Kay, Elaine W.
术前放化疗用于局部晚期直肠癌，可减少局部复发，提高可操作性，但仍有一部分肿瘤没有明显的消退。确定对放化疗反应的预测标记将改善患者的选择，并可能通过靶向特定途径来改变反应。本研究的目的是确定预处理直肠癌活检中葡萄糖转运蛋白-1 （GLUT-1）和p53的表达是否能预测肿瘤对放化疗的反应。对69例预处理活检进行GLUT-1和p53的免疫组化染色，并通过肿瘤消退等级（TRG）评分系统与切除标本的肿瘤反应进行比较。GLUT-1表达与放化疗反应降低显著相关，GLUT表达增加与放化疗反应较差相关（p = 0.02）。GLUT-1阴性肿瘤有70%的良好反应概率（TRG3/4），而GLUT-1阳性肿瘤有31%的良好反应概率。GLUT-1可能是直肠癌放化疗反应的有用预测指标。(c) 2009年
Preoperative chemoradiotherapy is used in locally advanced rectal cancer to reduce local recurrence and improve operability, however a proportion of tumors do not undergo significant regression. Identification of predictive markers of response to chemoradiotherapy would improve patient selection and may allow response modification by targeting of specific pathways. The aim of this study was to determine whether expression of glucose transporter-1 (GLUT-1) and p53 in pretreatment rectal cancer biopsies was predictive of tumor response to chemoradiotherapy. Immunohistochemical staining for GLUT-1 and p53 was performed on 69 pretreatment biopsies and compared to tumor response in the resected specimen as determined by the tumor regression grade (TRG) scoring system. GLUT-1 expression was significantly associated with reduced response to chemoradiotherapy and increasing GLUT expression correlated with poorer response (p = 0.02). GLUT-1 negative tumors had a 70% probability of good response (TRG3/4) compared to a 31% probability of good response in GLUT-1 positive tumors. GLUT-1 may be a useful predictive marker of response to chemoradiotherapy in rectal cancer. (C) 2009 UICC