A SILICON MICROMACHINED DEVICE FOR USE IN BLOOD-CELL DEFORMABILITY STUDIES
A SILICON MICROMACHINED DEVICE FOR USE IN BLOOD-CELL DEFORMABILITY STUDIES
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DOI：
10.1109/10.398635
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发表时间：
1995-08-01
影响因子：
4.6
通讯作者：
BARNES, AJ
中科院分区：
文献类型：
--
作者：
TRACEY, MC;GREENAWAY, RS;BARNES, AJ
硅微机械加工的血细胞流变学分析的应用进行了说明。该系统，基于微机械加工的流动池，提供了一个特定的测量的每个细胞在统计学上显着的人口方面的流速分布和细胞体积的指数，而细胞流过微通道阵列。讨论了硅微机械流动池的原理、设计和制作。确定相关的流体，机械，成像和实时图像分析子系统的设计相互关联的考虑因素进行检查。样本数据比较正常和缺铁性贫血的血液，以说明这种技术的潜力。
An application of silicon micromachining to the analysis of blood cell theology is described. The system, based upon a micromachined flow cell, provides a specific measurement of each cell in a statistically significant population in terms of both flow velocity profile and an index of cell volume while the cells flow through an array of microchannels. The-rationale, design, and fabrication of the silicon micromachined flow cell is discussed. Interrelated considerations determining the design of the associated fluidic, mechanical, imaging, and real-time image analysis subsystems are examined. Sample data comparing normal and iron deficiency anaemic blood are presented to illustrate the potential of this technique.