CORTICAL SPREADING DEPRESSION REDUCES DURAL BLOOD-FLOW - A POSSIBLE MECHANISM FOR MIGRAINE PAIN
CORTICAL SPREADING DEPRESSION REDUCES DURAL BLOOD-FLOW - A POSSIBLE MECHANISM FOR MIGRAINE PAIN
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DOI：
10.1046/j.1468-2982.1994.1406430.x
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发表时间：
1994-12-01
期刊：
影响因子：
4.9
通讯作者：
MICHALICEK, J
中科院分区：
文献类型：
--
作者：
LAMBERT, GA;MICHALICEK, J
These experiments were designed to investigate a possible mechanism linking the phenomenon of cortical spreading depression with activation of the trigeminal sensory system in migraine. Blood flow in the cortex and middle meningeal artery was measured in cats before and during propagation of a wave of cortical spreading depression, initiated by cortical pin-prick. This caused a transient propagated increase in cortical blood flow. Cortical spreading depression was accompanied by a decrease in blood flow in the middle meningeal artery, sometimes to very low levels. The results suggest that the pain of migraine could arise from dural ischemia induced by cortical spreading depression.
