A realistic phantom for validating MRI-based synthetic CT images of the human skull
A realistic phantom for validating MRI-based synthetic CT images of the human skull
复制标题
DOI：
10.1002/mp.12428
复制
发表时间：
2017-09-01
期刊：
影响因子：
3.8
通讯作者：
Chugh, Brige P.
中科院分区：
文献类型：
--
作者：
Soliman, Abraam S.;Burns, Levi;Chugh, Brige P.
目的：介绍一种新的逼真的人类颅骨体模的合成CT图像的皮质骨从超短回波时间（UTE）sequences.Methods的验证：一个成年女性的人类颅骨被利用作为一个现实的表示颅骨皮质骨。头骨被固定在一个特殊的丙烯酸容器中，并填充了具有与人脑相似的T-1和T-2弛豫时间的造影剂。在3 T下使用UTE和T-2加权序列对体模进行MR扫描，然后进行CT扫描。提出了一种聚类方法来提取MR图像中的骨皮质信号。计算颅骨的T-2（*）图。合成的CT图像的骨皮质骨信号提取的CT图像和混杂因素，如配准误差，进行了analysed.Results：骰子相似系数（DSC）的UTE检测皮质骨为0.84，并逐渐减少辐条的数量。DSC没有显着依赖于回波时间。登记错误被发现是显着的混杂因素，在DSC一致的2毫米误差在每个axis.Conclusion：这项工作介绍了一种新的现实的人类颅骨体模，专门为皮质骨的合成CT图像的评价和分析，减少25%。(C)2017年美国医学物理学家协会
Purpose: To introduce a new realistic human skull phantom for the validation of synthetic CT images of cortical bone from ultra-short echo-time (UTE) sequences.Methods: A human skull of an adult female was utilized as a realistic representation of skull cortical bone. The skull was stabilized in a special acrylic container and was filled with contrast agents that have T-1 and T-2 relaxation times similar to human brain. The phantom was MR scanned at 3T with UTE and T-2-weighted sequences, followed by CT. A clustering approach was developed to extract the cortical bone signal from MR images. T-2(*) maps of the skull were calculated. Synthetic CT images of the bone were compared to cortical bone signal extracted from CT images and confounding factors, such as registration errors, were analyzed.Results: Dice similarity coefficient (DSC) of UTE-detected cortical bone was 0.84 and gradually decreased with decreasing number of spokes. DSC did not significantly depend on echo-time. Registration errors were found to be significant confounding factors, with 25% decrease in DSC for consistent 2 mm error at each axis.Conclusion: This work introduced a new realistic human skull phantom, specifically for the evaluation and analysis of synthetic CT images of cortical bone. (C) 2017 American Association of Physicists in Medicine