Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children.
Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children.
复制标题
血液的剂量效应和剂量反应关系导致幼儿红细胞原卟啉。
DOI：
10.1016/0013-9351(85)90083-0
复制
发表时间：
1985
影响因子：
8.3
通讯作者：
Succop,P
中科院分区：
文献类型：
--
作者：
Hammond,PB;Bornschein,RL;Succop,P
使用来自165名3-36个月儿童的多个数据点，分析血铅浓度（PbB）与血原卟啉浓度的剂量-效应和剂量-反应关系。使用设计用于测量锌原卟啉（ZPP）的前表面荧光计和设计用于测量总原卟啉游离碱（FEP）的提取方法测量原卟啉浓度。估算了PbB对FEP和ZPP影响的阈值，以及PbB-FEP和PbB-ZPP相互作用的斜率。使用ZPP与FEP作为效应参数估计的阈值基本上没有差异。年龄对阈值无明显影响。然而，PbB与ZPP的斜率不如PbB与FEP的斜率陡。此外，FEP：ZPP的平均比值在3个月时显著升高（1.84：1），并缓慢下降，在33个月时达到1。这种差异的可能原因进行了讨论，以及铅筛查程序数据的解释的影响。
Dose-effect and dose-response relationships were analyzed for blood lead concentration (PbB) vs blood protoporphyrin concentration using multiple data points from 165 children, ages 3–36 months. Protoporphyrin concentrations were measured using a front-face flurometer designed to measure zinc protoporphyrin (ZPP) and an extraction method designed to measure total protoporphyrin as the free base (FEP). Estimations were made of the threshold for PbB effects on FEP and ZPP, as well as the slopes of the PbB-FEP and PbB-ZPP interactions. There was essentially no difference in thresholds estimated using ZPP vs FEP as the effect parameter. There was no apparent effect of age on threshold. However, the slope for PbB vs ZPP was less steep than the slope for PbB vs FEP. Moreover, the average ratio FEP:ZPP was markedly elevated at 3 months (1.84:1) and decreased slowly, attaining unity at 33 months. The possible reasons for this discrepancy are discussed, as well as the implications for interpretation of lead screening program data.