Single-trial analysis of oddball event-related potentials in simultaneous EEG-fMRI
Single-trial analysis of oddball event-related potentials in simultaneous EEG-fMRI
复制标题
DOI：
10.1002/hbm.20289
复制
发表时间：
2007-07-01
影响因子：
4.8
通讯作者：
Anton, Jean-Luc
中科院分区：
文献类型：
--
作者：
Benar, Christian-G.;Schon, Daniele;Anton, Jean-Luc
近年来，使用同步脑电(EEG)和功能磁共振成像(FMRI)来研究认知范式中的诱发活动，从而获得具有高空间和时间分辨率的功能数据集，受到了越来越多的关注。同时记录可以在相同的环境、刺激条件和受试者状态下获得事件相关电位(ERPs)和MR图像，还可以跟踪EEG和fMRI信号的联合波动。这项研究的目的是调查跟踪事件相关脑电活动的试验到试验变化的可能性，并将该信息用作FMR1分析的参数。我们使用了一种奇怪的听觉范式，并从fMRI扫描过程中获得的脑电获得了单次尝试的幅度和潜伏期特征。单次P300潜伏期与脑电外部参数(靶-靶间期和反应时)显著相关。此外，我们获得了显著的功能磁共振激活的调制P300的幅度和潜伏期，无论是在单个受试者和在群体水平。我们的结果表明，与其他研究一样，脑电通过提供关于大脑活动波动的精细时间信息，可以为功能磁共振分析领域带来一个新的维度。
There has recently been a growing interest in the use of simultaneous electroencephalography (EEG) and functional MRI (fMRI) for evoked activity in cognitive paradigms, thereby obtaining functional datasets with both high spatial and temporal resolution. The simultaneous recording permits obtaining event-related potentials (ERPs) and MR images in the same environment, conditions of stimulation, and subject state; it also enables tracing the joint fluctuations of EEG and fMRI signals. The goal of this study was to investigate the possibility of tracking the trial-to-trial changes in event-related EEG activity, and of using this information as a parameter in fMR1 analysis. We used an auditory oddball paradigm and obtained single-trial amplitude and latency features from the EEG acquired during fMRI scanning. The single-trial P300 latency presented significant correlation with parameters external to the EEG (target-to-target interval and reaction time). Moreover, we obtained significant fMRI activations for the modulation by P300 amplitude and latency, both at the single-subject and at the group level. Our results indicate that, in line with other studies, the EEG can bring a new dimension to the field of fMRI analysis by providing fine temporal information on the fluctuations in brain activity.