Anticancer effects of Huaier are associated with down-regulation of P53.

Anticancer effects of Huaier are associated with down-regulation of P53.
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DOI：
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发表时间：
2011
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
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通讯作者：
Xiao Xu;Q. Wei;Kai Wang;Q. Ling;Haiyang Xie;Lin Zhou;Shusen Zheng
Xiao Xu;Q. Wei;Kai Wang;Q. Ling;Haiyang Xie;Lin Zhou;Shusen Zheng
中科院分区：
其他
文献类型：
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作者：
Xiao Xu;Q. Wei;Kai Wang;Q. Ling;Haiyang Xie;Lin Zhou;Shusen Zheng

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本研究旨在探讨槐耳抗实验性肝癌的作用机制。将75只大鼠分为5组，分别给予N-亚硝基二乙胺（B、C、D、E组）和生理盐水（A组）。C、E组同时给予槐耳液灌胃。在15周处死时，C组肝癌发生率低于血清AFP相关组。B组血清ALT浓度和P53 mRNA水平均高于C组（分别为98.9%和23.2%）。D组和E组的长期生存率无显著差异。槐耳对化学性肝损伤有保护作用，可能与下调P53有关。
This study was designed to explore the mechanism of Huaier anticancer effects on experimental hepatocellular cancer (HCC) development. Seventy five rats were divided into 5 groups, administered N-nitrosodiethylamine (groups B, C, D and E) or natural saline (group A). Rats in group C and E were also given Huaier. At the 15 week sacrifice point, the HCC incidence of group C was lower than group correlating with serum AFP. The serum ALT concentration (98.9% greater) and P53 mRNA levels (23.2%) were higher in Group B than group C. Longer term survival rates between group D and E were not significantly different. Huaier can protect liver from chemical injury and furthermore HCC development, possibly with involvement of down-regulation of P53.