Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual-Modal Imaging-Guided Photothermal-Chemotherapy of Triple Negative Breast Cancer.
Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual-Modal Imaging-Guided Photothermal-Chemotherapy of Triple Negative Breast Cancer.
复制标题
周期性介孔有机硅涂层普鲁士蓝用于 MR/PA 双模态成像引导三阴性乳腺癌光热化疗
DOI：
10.1002/advs.201600356
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Lu G
中科院分区：
文献类型：
--
作者：
Tian W;Su Y;Tian Y;Wang S;Su X;Liu Y;Zhang Y;Tang Y;Ni Q;Liu W;Dang M;Wang C;Zhang J;Teng Z;Lu G
完全根除高度侵袭性三阴性乳腺癌（TNBC）今天仍然是一个显着的挑战。在这项工作中，基于周期性介孔有机二氧化硅（PMO）涂层普鲁士蓝（PB@PMO）纳米平台，首次开发了TNBC的成像引导光热化疗策略。PB@PMOs具有有机-无机混合框架，直径均匀（125 nm），高表面积（866 m2 g−1），大孔径（3.2 nm），出色的光热转换能力，高药物负载能力（260µg mg−1），以及磁共振（MR）和光声（PA）成像能力。PB@PMOs的MR和PA特性有助于肿瘤成像和显示肿瘤区域纳米平台的积累。MDA - MB - 231 - Luc荷瘤小鼠模型的生物发光强度和肿瘤体积表明，与单一治疗策略相比，光热联合化疗可有效抑制TNBC。组织病理学分析进一步表明，联合治疗导致肿瘤中最广泛的凋亡和坏死细胞，对主要器官没有明显的副作用。
Complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. In this work, an imaging‐guided photothermal‐chemotherapy strategy for TNBC is developed for the first time based on a periodic mesoporous organosilica (PMO) coated Prussian blue (PB@PMO) nanoplatform. The PB@PMOs have organic‐inorganic hybrid frameworks, uniform diameter (125 nm), high surface area (866 m2 g−1), large pore size (3.2 nm), excellent photothermal conversion capability, high drug loading capacity (260 µg mg−1), and magnetic resonance (MR) and photoacoustic (PA) imaging abilities. The MR and PA properties of the PB@PMOs are helpful for imaging the tumor and showing the accumulation of the nanoplatform in the tumor region. The bioluminescence intensity and tumor volume of the MDA‐MB‐231‐Luc tumor‐bearing mouse model demonstrate that TNBC can be effectively inhibited by the combined photothermal‐chemotherapy than monotherapy strategy. Histopathological analysis further reveals that the combination therapy results in most extensive apoptotic and necrotic cells in the tumor without inducing obvious side effect to major organs.