Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration
Expression of specific white adipose tissue genes in denervation-induced skeletal muscle fatty degeneration
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DOI：
10.1016/s0014-5793(98)01216-2
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发表时间：
1998-11-13
期刊：
影响因子：
3.5
通讯作者：
Bacou, F
中科院分区：
文献类型：
--
作者：
Dulor, JP;Cambon, B;Bacou, F
骨骼肌的去神经支配导致快速萎缩，收缩量减少和/或肌纤维进行性变性，肌纤维或多或少地被结缔组织和脂肪组织所取代。在这项研究中，我们表明，失去神经的兔子肌肉转化为白色脂肪组织，这取决于它们的纤维类型。该组织不表达LPL、G3PDH，特别是ob基因，一种白色脂肪组织特异性标记，不表达棕色脂肪组织分子标记UCP1 mRNA。(C) 1998年欧洲生化学会联合会。
Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue-specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA. (C) 1998 Federation of European Biochemical Societies.