Effect of cerebral spinal fluid suppression for diffusional kurtosis imaging
Effect of cerebral spinal fluid suppression for diffusional kurtosis imaging
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DOI：
10.1002/jmri.23840
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发表时间：
2013-02-01
影响因子：
4.4
通讯作者：
Helpern, Joseph A.
中科院分区：
文献类型：
--
作者：
Yang, Alicia W.;Jensen, Jens H.;Helpern, Joseph A.
目的：评价脑脊液（CSF）部分容积对白色物质和皮质灰质弥散峰度成像（DKI）指标的影响。材料与方法：4名健康志愿者参加了这项研究。使用二次重聚焦自旋回波扩散序列进行标准DKI和液体衰减反转恢复（FLAIR）DKI实验。测量并比较了分数各向异性（FA）、平均扩散率、轴向扩散率和径向扩散率（MD、D平行于、D垂直于）的常规弥散张量成像（DTI）指标以及平均、轴向和径向峰度（MK、K平行于、K垂直于）的DKI指标。选择位于侧脑室上方的单个图像切片，每例受试者具有相似的解剖特征，以最大限度地减少来自脑室的CSF的影响。结果如下：在白色物质中，观察到标准DKI和FLAIR-DKI序列测量的扩散度量之间的差异小于10%，表明CSF污染最小。对于灰质，常规DTI指标相差19%至52%，反映了显著的CSF部分容积效应。然而，峰度指标的变化为11%或更少，表明CSF污染的稳健性更高。结论：峰度指标对皮质灰质中CSF部分体积的敏感性低于传统的扩散指标。如果变化的效应大小具有可比性，那么峰度指标可能是组织微观结构变化的更具体指标。J.磁共振Imaging 2013;37：365371. (C)2012 Wiley Periodicals，Inc.
Purpose: To evaluate the cerebral spinal fluid (CSF) partial volume effect on diffusional kurtosis imaging (DKI) metrics in white matter and cortical gray matter. Materials and Methods: Four healthy volunteers participated in this study. Standard DKI and fluid-attenuated inversion recovery (FLAIR) DKI experiments were performed using a twice-refocused-spin-echo diffusion sequence. The conventional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, D parallel to, D perpendicular to together with DKI metrics of mean, axial, and radial kurtosis (MK, K parallel to, K perpendicular to), were measured and compared. Single image slices located above the lateral ventricles, with similar anatomical features for each subject, were selected to minimize the effect of CSF from the ventricles. Results: In white matter, differences of less than 10% were observed between diffusion metrics measured with standard DKI and FLAIR-DKI sequences, suggesting minimal CSF contamination. For gray matter, conventional DTI metrics differed by 19% to 52%, reflecting significant CSF partial volume effects. Kurtosis metrics, however, changed by 11% or less, indicating greater robustness with respect to CSF contamination. Conclusion: Kurtosis metrics are less sensitive to CSF partial voluming in cortical gray matter than conventional diffusion metrics. The kurtosis metrics may then be more specific indicators of changes in tissue microstructure, provided the effect sizes for the changes are comparable. J. Magn. Reson. Imaging 2013;37:365371. (C) 2012 Wiley Periodicals, Inc.