Oxidative reactivity across kingdoms in the gut: Host immunity, stressed microbiota and oxidized foods.
Oxidative reactivity across kingdoms in the gut: Host immunity, stressed microbiota and oxidized foods.
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DOI：
10.1016/j.freeradbiomed.2021.11.009
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发表时间：
2021-11
影响因子：
7.4
通讯作者：
Bahda Yun;M. King;Mohamed S. Draz;T. Kline;A. Rodriguez-Palacios
中科院分区：
文献类型：
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作者：
Bahda Yun;M. King;Mohamed S. Draz;T. Kline;A. Rodriguez-Palacios
活性氧在诱导程序性细胞死亡和许多疾病中起主要作用。活性氧物质的产生在生物系统如人类、细菌、真菌/酵母和植物中普遍存在。虽然已知活性氧会引起疾病，但对肠道中组合氧化应激负荷的重要性知之甚少。了解动态和水平的氧化应激反应性的王国可以帮助确定的综合后果的自由基积累在肠道内腔。在这里，我们提出了来自宿主免疫细胞，细菌，酵母，植物和therein衍生的饮食，这往往加重了自由基的负担，在储存和烹饪条件下积累的氧化应激的基本相似性。鉴于所描述的相似性，通过监测粪便中的氧化应激水平以识别促炎因子，可以更好地理解氧化应激并将其最小化。然而，我们说明，饮食研究很少监测粪便中的氧化应激标志物，因此我们对粪便氧化应激监测的知识是有限的。一种更全面的方法来理解肠道中的氧化应激“反应性”，可以帮助改善使用饮食和微生物群预防肠道疾病的策略。
Reactive oxygen species play a major role in the induction of programmed cell death and numerous diseases. Production of reactive oxygen species is ubiquitous in biological systems such as humans, bacteria, fungi/yeasts, and plants. Although reactive oxygen species are known to cause diseases, little is known about the importance of the combined oxidative stress burden in the gut. Understanding the dynamics and the level of oxidative stress ‘reactivity’ across kingdoms could help ascertain the combined consequences of free radical accumulation in the gut lumen. Here, we present fundamental similarities of oxidative stress derived from the host immune cells, bacteria, yeasts, plants, and the therein-derived diets, which often accentuate the burden of free radicals by accumulation during storage and cooking conditions. Given the described similarities, oxidative stress could be better understood and minimized by monitoring the levels of oxidative stress in the feces to identify pro-inflammatory factors. However, we illustrate that dietary studies rarely monitor oxidative stress markers in the feces, and therefore our knowledge on fecal oxidative stress monitoring is limited. A more holistic approach to understanding oxidative stress ‘reactivity’ in the gut could help improve strategies to use diet and microbiota to prevent intestinal diseases.