Impact of Renin-Angiotensin System Polymorphisms on Development of Systolic Dysfunction in Hypertrophic Cardiomyopathy - Evidence From a Study of Genotyped Patients
Impact of Renin-Angiotensin System Polymorphisms on Development of Systolic Dysfunction in Hypertrophic Cardiomyopathy - Evidence From a Study of Genotyped Patients
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DOI：
10.1253/circj.cj-10-0482
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发表时间：
2010-12-01
影响因子：
3.3
通讯作者：
Yamagishi, Masakazu
中科院分区：
文献类型：
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作者：
Funada, Akira;Konno, Tetsuo;Yamagishi, Masakazu
背景：虽然肾素血管紧张素系统（RAS）可以影响左心室（LV）肥厚的发展，但关于 RAS 多态性与 LV 功能改变之间关系的数据很少。本研究探讨了基因型肥厚型心肌病 (HCM) 中 RAS 多态性对左室功能的影响。 方法和结果：研究组由来自 49 个 HCM 家族的 126 名肌节基因突变携带者组成（64 名男性，平均年龄 51 +/- 21 岁），通过超声心动图评估左室形态和功能。在血管紧张素转换酶 (ACE) 插入/删除 (I/D) 中，D 等位基因 (n=81) 表现出比 II 基因型 (分别为 28 +/- 7 mm 和 62 +/- 12%) 显着更大的 LV 收缩末期 (LVD) (32 +/- 11 mm) 和更低的射血分数 (56 +/- 15%) P
Background: Although the renin angiotensin system (RAS) can affect the development of left ventricular (LV) hypertrophy, few data exist regarding the relationships between RAS polymorphisms and alteration of LV function. The effect of RAS polymorphisms on LV function in genotyped hypertrophic cardiomyopathy (HCM) was examined in the present study.Methods and Results: The study group comprised 126 carriers with sarcomere gene mutations from 49 HCM families (64 males, mean age 51 +/- 21 years) LV morphology and function were evaluated by echocardiography. In angiotensin-converting enzyme (ACE) insertion/deletion (I/D), the D allele (n=81) exhibited significantly larger LV end-systolic dimension (LVDs) (32 +/- 11 mm) and lower ejection fraction (56 +/- 15%) than those with the II genotype (28 +/- 7 mm and 62 +/- 12%, respectively P