RISK-FACTORS FOR WORSENING TO DIABETES IN SUBJECTS WITH IMPAIRED GLUCOSE-TOLERANCE
RISK-FACTORS FOR WORSENING TO DIABETES IN SUBJECTS WITH IMPAIRED GLUCOSE-TOLERANCE
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DOI：
10.1007/bf00252262
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发表时间：
1984-01-01
期刊：
影响因子：
8.2
通讯作者：
KOSAKA, K
中科院分区：
文献类型：
--
作者：
KADOWAKI, T;MIYAKE, Y;KOSAKA, K
在一项对288名糖耐量受损受试者进行的5-12年随访研究中，48名受试者在100 g葡萄糖负荷后恶化为明显的2型（非胰岛素依赖型）糖尿病，空腹血糖升高。血糖的初始水平是随后恶化为糖尿病的主要预测因素。此外，无论血糖水平如何，对葡萄糖的胰岛素反应较低的受试者显示疾病恶化的发生率较高。多变量分析表明，在日本受试者中，胰岛素反应减弱和最大体重指数[肥胖]较高，以及初始100 g口服葡萄糖耐量试验时空腹和2小时血糖值较高，是发生糖尿病的重要独立危险因素。
In a 5-12 yr follow-up study of 288 subjects with impaired glucose tolerance after a 100-g glucose load, 48 worsened to overt Type 2 (non-insulin-dependent) diabetes with the elevation of fasting blood glucose. The initial level of blood glucose was a major predictor of subsequent worsening to diabetes. In addition, subjects with a lower insulin response to glucose showed a higher incidence of worsening to the disease, irrespective of blood glucose levels. Multivariate analysis indicated that a diminished insulin response and a high maximal body wt index [obesity], as well as a high level of fasting and 2-h glucose values at the initial 100-g oral glucose tolerance test were significant independent risk factors for the development of diabetes in Japanese subjects.