Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants
Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants
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DOI：
10.1016/j.ogc.2011.02.019
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发表时间：
2011-06-01
影响因子：
3.2
通讯作者：
Drever, Nathan
中科院分区：
文献类型：
--
作者：
Costantine, Maged M.;Drever, Nathan
脑瘫是儿童神经运动障碍的主要原因，与早产密切相关。基础科学研究和一些观察性研究表明，产前接触硫酸镁具有神经保护作用。最近的随机对照研究和荟萃分析表明，在预期早产前产前暴露于硫酸镁与存活婴儿发生脑瘫或其相关神经功能障碍的风险降低相关。更重要的是这一益处的实现并没有增加围产期死亡的风险。
Cerebral palsy is a leading cause of childhood neuromotor disability and is strongly associated with preterm delivery. Basic science research and some observational studies have suggested a neuroprotective benefit from antenatal exposure to magnesium sulfate. Recent randomized controlled studies and meta-analyses suggest that antenatal exposure to magnesium sulfate before anticipated preterm birth is associated with reduction in the risk of developing cerebral palsy or its associated neurologic disabilities in surviving infants. More importantly. this benefit has been achieved without increasing the risk of perinatal mortality.