Embryonic Stem Cells Go Dopaminergic
Embryonic Stem Cells Go Dopaminergic
复制标题
胚胎干细胞具有多巴胺能
DOI：
10.1016/s0896-6273(00)00079-9
复制
发表时间：
2000
期刊：
影响因子：
16.2
通讯作者：
A. Rosenthal
中科院分区：
文献类型：
--
作者：
M. Hynes;A. Rosenthal
Have a Lot of Potential ducing oligodendrocytes, the ES-derived glial precursor Stem cells are a major component of the early embryo, cells differentiated to functional oligodendrocytes, which but also exist in many adult tissues. Embryonic stem were able to myelinate axons in the brain and spinal (ES) cells are derived from the inner cell mass of the cord (Liu et al., 2000). Similarly, another group showed embryonic blastula, and this small group of cells (13 at that the exposure of ES cells to retinoic acid prompted the 64 cell stage embryo) will normally give rise to the them to produce glutaminergic, GABAergic, and glyentire embryonic yolk sac, the allantois, and the amnion. cinergic neurons (Gottlieb and Huettner, 1999) that, ES cells can be maintained indefinitely as pluripotent when transplanted into the rat spinal cord 9 days after stem cells in tissue culture. However, when injected into a traumatic injury, elicited partial functional recovery the blastocyst of a host mouse embryo, the donor ES(McDonald et al., 1999). cells integrate into the host inner cell mass and give rise Possible Utility in Parkinson’s Disease to descendants in all tissues of the resulting chimeric Identifying the conditions required for neural cell inducoffspring, including germ cells. When injected under the tion of ES cells may be particularly useful for the treatskin of an adult nude mouse or grown without essential ment of a progressive neurodegenerative disorder such growth factors in vitro, ES cells give rise to a random as Parkinson’s disease. Parkinson’s disease (PD), which collection of differentiated cells and tissues including afflicts over a 1 million people in the US, is characterized heart, muscle, blood islands, neurons, pigmented cells, by the degeneration and death of midbrain neurons that macrophages, epithelia, and adipocytes. produce the neurotransmitter dopamine, resulting in Whereas embryonic stem cells are transient, adult tremorsatrest, aninabilitytoinitiateorcompleteroutine stemcellsappeartoresidepermanentlyinmosttissues, movements, muscle rigidity, postural instability, and including the brain, bone marrow stroma, liver, skin, and lack of facial expression. Transplantation of dopaminermuscle. Adult stem cells were initially thought to be gicneurons (DAneurons) takenfromhumanfetusesinto limited in their developmental potential to the regenera- PD patients shows a remarkable, yet inconsistent, ability tion of cell types comprising their tissues of origin. How- to replace endogenous degenerating DA neurons and ever, in a recent study, stem cells from the adult brain to ameliorate some of the disease symptoms (Bjorklund and Lindvall, 2000). However, since treatment of a single PD patient requires DA neurons from six to ten human
DOI：
10.1073/pnas.97.11.6126
发表时间：
2000-05-23
影响因子：
11.1
作者：
Liu, S;Qu, Y;McDonald, JW
通讯作者：
McDonald, JW