Postinflammatory hyperpigmentation after human cold pain testing.
Postinflammatory hyperpigmentation after human cold pain testing.
复制标题
人体冷痛测试后炎症后色素沉着过度。
DOI：
10.1097/pr9.0000000000000569
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发表时间：
2016
期刊：
影响因子：
4.8
通讯作者：
Kolber,BenedictJ
中科院分区：
文献类型：
--
作者：
Wolz,MelissaJ;Sadler,KatelynE;Long,CaelaC;Brenner,DanielS;Kim,BrianS;Gereau4th,RobertW;Kolber,BenedictJ
低温敏感性的变化通常与慢性疼痛有关。在了解这些变化背后的神经生物学机制以及由此产生的有效疗法的进展方面，由于用于测量人类热敏性的设备的可及性和可负担性，进展缓慢。为了解决这一差距，我们开发了一种廉价的方法来测量健康成年志愿者的冷痛阈值，使用干冰和热模。然而，在早期的初步测试中，一名受试者表现为表皮炎症后色素沉着，持续时间为。200天。虽然这种反应在少量受试者中是独一无二的，但它提出了分析设计安全性的问题。
Abstract Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for. 200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.