ALTERED IMMUNOLOGICAL COMPETENCE OF NEONATAL MICE FORCE FED ALLOGENEIC LYMPHOID CELLS
ALTERED IMMUNOLOGICAL COMPETENCE OF NEONATAL MICE FORCE FED ALLOGENEIC LYMPHOID CELLS
复制标题
强制喂养同种异体淋巴细胞的新生小鼠免疫能力的改变
DOI：
10.1097/00007890-197812000-00017
复制
发表时间：
1978
期刊：
影响因子：
6.2
通讯作者：
R. C. Parks
中科院分区：
文献类型：
--
作者：
B. K. Dutmers;R. C. Parks
进行一项研究，以评价成年BALB/c（H-2d）小鼠在分娩后不久（<12小时）强制喂食104、106或108 DBA/1（H-2 q）淋巴细胞的免疫反应性。7周龄时，用DBA/1同种异体皮肤移植物检测其免疫反应性。接受104个同种异体淋巴样细胞的小鼠表现出加速的移植物排斥反应，而接受106或108个同种异体淋巴样细胞的小鼠显示出与同窝对照组无显著差异的同种异体移植物中位存活时间（MST）。3/30和2/14小鼠强制喂食106和108同种异体淋巴细胞表现出延长的皮肤移植物的生存期，从22天到55天不等。这些小鼠中没有一只在婴儿期观察到侏儒症的症状，尽管侏儒症确实发生在强制喂养的新生儿中，并且在接受108同种异体淋巴细胞的新生儿中最严重。然而，Runting病的发生率并不像那些从出生起就由DBA/1母亲喂养或静脉注射5 × 106 DBA/1淋巴细胞的新生儿那样高。这项研究的结果表明，哺乳动物摄入淋巴细胞可以影响成年人的免疫反应。
SUMMARY A study was entered upon to evaluate the immunological reactivity of adult BALB/c (H-2d) mice force fed either 104, 106, or 108 DBA/1 (H-2q) lymphoid cells shortly (<12 hr) after parturition. When these mice were 7 weeks old, their immunological responsiveness was tested with DBA/1 skin allografts. Mice receiving 104 allogeneic lymphoid cells demonstrated an accelerated graft rejection, whereas those that received 106 or 108 allogeneic lymphoid cells displayed an allograft median survival time (MST) that was not significantly different from that of the littermate controls. Three of 30 and 2 of 14 mice force fed 106 and 108 allogeneic lymphoid cells demonstrated a prolonged survival of skin allograft ranging from 22 to 55 days. None of these mice were observed to have symptoms of runting disease while infants, although runting disease did occur in the force-fed neonates and was greatest in those receiving 108 allogeneic lymphoid cells. However, the frequency of runting disease was not as great as in those neonates either nursed from birth on DBA/1 mothers or injected i.v. with 5 × 106 DBA/1 lymphoid cells. The results of this study suggest that the ingestion of lymphoid cells by suckling can influence the immunological responsiveness of an adult.