A fully integrated graphene-polymer field-effect transistor biosensing device for on-site detection of glucose in human urine
A fully integrated graphene-polymer field-effect transistor biosensing device for on-site detection of glucose in human urine
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DOI：
10.1016/j.mtchem.2021.100635
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发表时间：
2021-11-25
影响因子：
7.3
通讯作者：
Pan, Y.
中科院分区：
文献类型：
--
作者：
Huang, C.;Hao, Z.;Pan, Y.
方便、快捷地自测体内葡萄糖水平，对于糖尿病患者及时了解自身健康状况具有重要意义。鉴于此，聚合物功能化的石墨烯场效应晶体管（P-GFET）便携式生物传感装置被证明用于葡萄糖监测。该聚合物由丙烯酰胺/3-丙烯酰胺基苯硼酸（AAPBA）/N，N-二甲氨基丙基丙烯酰胺合成。在葡萄糖存在的情况下，由于石墨烯上合成的聚合物中葡萄糖和AAPBA之间的共价键，P-GFET显示出狄拉克点位移和电流变化。随着聚合物中AAPBA浓度的增加，这种P-GFET传感器的灵敏度可以增加。由于聚合物与葡萄糖之间的可逆反应，所用传感器经盐酸处理后可恢复检测能力。此外，高分子与葡萄糖之间的化学吸附相互作用，这是强于物理吸附与其他物体在尿液中的相互作用，已被支持的密度泛函理论研究。P-GFET显示出822 μ A*cm（-2）*mM（-1）的高灵敏度，在人尿糖监测期间检测限为1.9 μ M。该传感器具有0.04-10 mM的检测范围和良好的可重复使用性超过20次。凭借定制的便携式尿液实时测量能力，我们的P-GFET传感器可以提供优于当前葡萄糖检测方法的优势。(C)2021爱思唯尔有限公司保留所有权利。
Convenient and rapid self-measurement of the glucose level in the body is of great significance for diabetics to know their health conditions in time. In view of this, a polymer functionalized graphene field-effect transistor (P-GFET) portable biosensing device is demonstrated for glucose monitoring. The polymer is synthesized by acrylamide/3-acrylamidophenylboronic acid (AAPBA)/N, N-dimethylaminopropyl acrylamide. In the presence of glucose, the P-GFET shows Dirac point shifts and current changes as a result of the covalent bond between glucose and AAPBA in the synthesized polymer on graphene. The sensitivity of this P-GFET sensor can increase while the density of AAPBA in polymer increases. The used sensor could regain the detection capability after hydrochloric acid treatment due to the reversible reaction between polymer and glucose. In addition, the chemisorption interaction between polymer and glucose, which is stronger than physisorption interaction with other objects in urine, has been supported by the density functional theory study. The P-GFET shows high sensitivity of 822 mu A*cm(-2)*mM(-1) with a limit of detection of 1.9 mu M during human urine glucose monitoring. The sensor holds a detection range of 0.04-10 mM and good reusability over 20 times. With the customized portable real-time measurement capability in urine, our P-GFET sensor can offer advantages over current glucose detection methods. (C) 2021 Elsevier Ltd. All rights reserved.