Cholesterol-lowering mechanisms of phytochemicals: a review
Cholesterol-lowering mechanisms of phytochemicals: a review
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植物化学物质的降胆固醇机制：综述
DOI：
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发表时间：
2017
影响因子：
0.5
通讯作者：
Kou Xiaohong
中科院分区：
文献类型：
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作者：
Xue Zhaohui;Wang Ru;Yu Wancong;Kou Xiaohong
植物化学物质因其显著的降胆固醇特性而引起了人们的注意。这篇综述着重于植物化学物质的研究，并讨论了降低血清胆固醇的可能机制。植物化学物质的降胆固醇作用与植物甾醇、酚类、皂苷、生物碱、有机硫化物、凝集素等有关。植物化学物质被证明能够减少胆固醇的摄取和自动合成，抑制胆固醇的乳化和酯化，促进胆汁酸的排泄或胆固醇的转移。Diff产生的植物化学物质可以对这些机制中的一个或多个起作用。植物甾醇还可能通过抑制膳食混合胶束的形成和NiemannPickC1样蛋白(NPC1L1)的表达而发挥作用，从而抑制胆固醇的吸收。多酚可能调节胆固醇酯转移蛋白(CETP)的活性，促进胆固醇的运输。最后，这些发现使使用植物化学物质来指导有益饮食的创造成为可能。
Phytochemicals have attracted attention due to.their substantial cholesterol-lowering properties. Tis review.focuses on studies conducted with phytochemicals and discusses.the probable mechanisms for serum cholesterol reduction. Te.cholesterol-lowering effects of phytochemicals were associated.with phytosterol, phenolics, saponins, alkaloids, organic sulfdes.and lectins. Phytochemicals were shown to be able to reduce food.intake and auto-synthesis of cholesterol, inhibit emulsifcation.and esterifcation of cholesterol, and promote excretion of bile.acid or transfer of cholesterol. Different phytochemicals can.contribute to one or more of these mechanisms. Phytosterols.may also exert their effects by suppressing the formation of.dietary mixed micelles (DMM) and expression of NiemannPick C1-Like1 (NPC1L1) to inhibit absorption of cholesterol..Polyphenols may regulate the activity of cholesteryl ester transfer.protein (CETP) to accelerate transportation of cholesterol..Finally, these fndings make it possible to use phytochemicals to.guide the creation of a benefcial diet.