Inclusion body myositis associated with human T-lymphotropic virus-type I infection: Eleven patients from an endemic area in Japan
Inclusion body myositis associated with human T-lymphotropic virus-type I infection: Eleven patients from an endemic area in Japan
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DOI：
10.1097/nen.0b013e31815f38b7
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Osame, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Matsuura, Eiji;Umehara, Fujio;Osame, Mitsuhiro
本研究的目的是探讨人类嗜T淋巴细胞病毒I型（HTLV-I）感染与散发性包涵体肌炎在11例日本流行区的关联。临床特征与散发性包涵体肌炎一致，所有患者血清中均存在抗HTLV-I抗体。他们的肌肉活检显示包涵体肌炎的诊断特征，包括肌内膜T细胞浸润、边缘空泡、磷酸化tau蛋白沉积以及肌纤维细胞核和细胞质中的异常细丝。纤维表达主要组织相容性复合物I类抗原，并被CD 8（+）和CD 4（+）细胞侵入。在1例人类白细胞抗原-A2阳性患者中，原位人类白细胞抗原-A *0201 /Tax 11 -19-五聚体染色显示肌纤维周围有五聚体阳性细胞。双免疫金银染色和聚合酶链反应原位杂交显示，HTLV-Ⅰ型前病毒DNA定位于辅助诱导T细胞，而不是在肌纤维。每个患者外周血单个核细胞中的人类嗜淋巴细胞病毒I型前病毒载量与HTLV-I相关脊髓病/热带痉挛性下肢轻瘫相似。这项研究表明，HTLV-I感染可能是散发性包涵体肌炎的原因之一，如已报告的人类免疫缺陷病毒I型感染。
The objective of this study was to investigate the association of human T-lymphotropic virus-type I (HTLV-I) infection with sporadic inclusion body myositis in 11 patients from an endemic area in Japan. The clinical features were consistent with sporadic inclusion body myositis, and anti-HTLV-I antibodies were present in the sera of all patients. Their muscle biopsies showed the diagnostic features of inclusion body myositis, including endomysial T-cell infiltration, rimmed vacuoles, deposits of phosphorylated tau, and abnormal filaments in the nuclei and cytoplasm of the myofibers. The fibers expressed major histocompatibility complex class I antigens and were invaded by CD8(+) and CD4(+) cells. In a single human leukocyte antigen-A2-positive patient, in situ human leukocyte antigen-A*0201 / Tax11-19-pentamer staining showed pentamer-positive cells surrounding the muscle fibers. Double-immunogold silver staining and polymerase chain reaction in situ hybridization revealed that HTLV-I proviral DNA was localized on helper-inducer T cells, but not on muscle fibers. Human llymphotropic virus-type I proviral loads in peripheral blood mononuclear cells from each patient were similar to those in HTLV-I-associated myelopathy/tropical spastic paraparesis. This study suggests that HTLV-I infection may be one of the causes of sporadic inclusion body myositis, as has been reported in human immunodeficiency virus type-I infection.