Longitudinal Study of Brain Asymmetries in Autism and Developmental Delays Aged 2-5 Years
Longitudinal Study of Brain Asymmetries in Autism and Developmental Delays Aged 2-5 Years
复制标题
自闭症大脑不对称和2-5岁发育迟缓的纵向研究
DOI：
10.1016/j.neuroscience.2020.02.028
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发表时间：
2020-04-15
期刊：
影响因子：
3.3
通讯作者：
Ke, Xiaoyan
中科院分区：
文献类型：
--
作者：
Fu, Linyan;Wang, Yue;Ke, Xiaoyan
一些先前的研究已经证明了自闭症谱系障碍（ASD）的非典型大脑侧化。然而，大多数这些报告集中在成人的语言相关的不对称，和半球不对称的发展轨迹发生在2-5岁的重要阶段仍然不清楚。因此，在本发明中，我们使用结构磁共振成像和扩散张量成像（DTI）对34名ASD幼儿和26名发育迟缓（DD）幼儿进行了一项纵向研究，研究对象为24岁的ASD幼儿，研究方法是使用基于体素的形态测量学和基于束的空间统计学（TBSS）对所有皮质包裹单位（PU）的灰质（GM）不对称性和整个白质骨架的白色（WM）偏侧化进行研究。3岁，4-5岁随访。结果发现，ASD组在基线和2年后的总脑体积和WM各向异性分数（FA）均高于DD组。ASD组和DD组在两个时间点的大量皮质PU和WM骨骼中均显示出不对称性。GM偏侧化与ASD基线时观察到的社交和沟通障碍相关，而WM不对称与4-5岁时观察到的社交障碍和重复行为显著相关。总之，ASD和DD幼儿都有广泛的侧偏不对称性，并且各组的侧化模式相似。GM和WM在2-5岁时表现出半球不对称的异步发展，这种偏侧化与ASD症状相关。(C)2020年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Some previous studies have demonstrated atypical brain lateralization in autism spectrum disorder (ASD). However, most of these reports have focused on language-related asymmetries in adults, and the developmental trajectory of hemispheric asymmetries in the important phase that occurs at 2-5 years of age remains unclear. Thus, we used structural magnetic resonance imaging and diffusion tensor imaging (DTI) in a longitudinal study of grey matter (GM) asymmetries across all cortical parcellation units (PUs) and white matter (WM) lateralization across the WM skeleton using voxel-based morphometry and tract-based spatial statistics (TBSS) in 34 toddlers with ASD and a matched group of 26 toddlers with developmental delay (DD) at 2-3 years old and with follow-up at 4-5 years of age. We found the total brain volume and fractional anisotropy (FA) of WM was higher in the ASD group than in the DD group at baseline and 2 years later. The ASD and DD groups showed a rightward asymmetry in a large number of cortical PUs and in the WM skeleton at both time points. GM lateralization was associated with the social and communicative disturbances observed in ASD at baseline, while WM asymmetry was significantly related to social disturbances and repetitive behaviours seen at 4-5 years of age. In conclusion, both ASD and DD toddlers had widespread rightward asymmetry, and the patterns of lateralization were similar across the groups. GM and WM showed asynchronous development of hemispheric asymmetries at 2-5 years of age, and this lateralization was associated with ASD symptoms. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.