Regulation of gene expression in the intestinal epithelium.
Regulation of gene expression in the intestinal epithelium.
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DOI：
10.1016/b978-0-12-381280-3.00009-9
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发表时间：
2010
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肠上皮内基因表达的调节是复杂的，并且由调节增殖和分化之间的平衡的各种信号传导途径控制。增殖是生长和替换通过凋亡和磨损丢失的细胞所必需的，然而在除了少数细胞之外的所有细胞中，必须发生分化以防止不受控制的生长（癌症）并提供基本功能。在本章中，我们将主要基于小鼠模型的数据，以及在调节肠道基因表达中起主要作用的特定形态发生素和转录因子家族，综述肠道上皮内基因表达调节的主要信号通路，包括：Hedgehog家族，叉头盒（FOX）因子，同源异型盒（HOX）基因，ParaHox基因，加塔转录因子，经典Wnt/β-连环蛋白信号传导，EPH/Ephrins，Sox 9，BMP信号传导，PTEN/PI 3 K、LKB 1、K-RAS、Notch通路、HNF和MATH 1。我们还将简要强调基因调控的重要新兴领域，包括microRNA和表观遗传调控。
Regulation of gene expression within the intestinal epithelium is complex and controlled by various signaling pathways that regulate the balance between proliferation and differentiation. Proliferation is required both to grow and to replace cells lost through apoptosis and attrition, yet in all but a few cells, differentiation must take place to prevent uncontrolled growth (cancer) and to provide essential functions. In this chapter, we will review the major signaling pathways underlying regulation of gene expression within the intestinal epithelium, based primarily on data from mouse models, as well as specific morphogens and transcription factor families that have a major role in regulating intestinal gene expression, including: the Hedgehog family, Forkhead Box (FOX) factors, Homeobox (HOX) genes, ParaHox genes, GATA transcription factors, canonical Wnt/β-catenin signaling, EPH/Ephrins, Sox9, BMP signaling, PTEN/PI3K, LKB1, K-RAS, Notch pathway, HNF and MATH1. We will also briefly highlight important emerging areas of gene regulation including microRNA and epigenetic regulation.