Diazepam treatment of early signs of exacerbation in schizophrenia.
Diazepam treatment of early signs of exacerbation in schizophrenia.
复制标题
地西泮治疗精神分裂症恶化的早期症状。
DOI：
10.1176/ajp.156.2.299
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Breier,AF
中科院分区：
文献类型：
--
作者：
CarpenterJr,WT;Buchanan,RW;Kirkpatrick,B;Breier,AF
在精神分裂症症状加重的最早阶段进行治疗干预是一个重要的临床需求，但尚未建立针对该疾病阶段的特定药物干预。本研究探讨了地西泮的疗效为这个阶段的treatment.METHODA双盲，随机临床试验与53例精神分裂症患者比较地西泮与安慰剂（与氟奋乃静治疗的对照组）。治疗开始于最早的症状加重，症状进展是用于评估efficacy. ESTSTSDiazepam的依赖措施是统计学上上级安慰剂在预防症状进展，是可比的fluphenazine.CONCLUSIONSEfficacy数据支持使用地西泮治疗前驱症状和早期预警症状加重精神分裂症。这种治疗策略对于拒绝抗精神病药物的患者或作为强调低剂量抗精神病药物治疗的治疗计划中的补充方法可能特别重要。
OBJECTIVETherapeutic intervention at the earliest phase of symptom exacerbation in schizophrenia is an important clinical need, but specific pharmacotherapeutic interventions for this phase of illness have not been established. This study examined diazepam efficacy for this phase of treatment.METHODA double-blind, randomized clinical trial with 53 schizophrenic patients compared diazepam with placebo (with fluphenazine treatment for a comparison group). Treatment was initiated at the earliest signs of exacerbation, and symptom progression was the dependent measure used to evaluate efficacy.RESULTSDiazepam was statistically superior to placebo in preventing symptom progression and was comparable to fluphenazine.CONCLUSIONSEfficacy data support the use of diazepam in treating prodromal and early warning signs of symptom exacerbation in schizophrenia. This therapeutic strategy may be especially important for patients who refuse antipsychotic drugs or as a supplemental approach in a treatment plan that emphasizes low-dose antipsychotic therapy.