Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder
Reduced thickness of anterior cingulate cortex in obsessive-compulsive disorder
复制标题
DOI：
10.1016/j.cortex.2012.09.001
复制
发表时间：
2013-09-01
期刊：
影响因子：
3.6
通讯作者：
Kathmann, Norbert
中科院分区：
文献类型：
--
作者：
Kuhn, Simone;Kaufmann, Christian;Kathmann, Norbert
简介：强迫症（OCD）的特征是一种重复的，侵入性的想法和行为，患者不想，但觉得他们必须执行。功能性脑成像显示，在强迫症涉及前扣带回皮质（ACC），眶额皮质（OFC），基底神经节功能障碍的途径。强迫症的结构改变进行了讨论，但分析工具，侧重于特定的形态方面，如皮质厚度已很少employed.Methods：我们获得了101名强迫症患者和95名健康对照组的MRI扫描。FreeSurfer分析软件进行建模的个人灰白色和软脑膜表面计算皮质厚度作为我们的目标measure.Results：相对于对照组，强迫症患者表现出皮质变薄的背侧和膝下ACC（错误发现率校正在p < .001），以及在其他几个地区内的额顶叶网络（错误发现率校正在p < .05）。皮质厚度不能预测从症状状态的全脑分析，但有一个适度的相关性，左背侧ACC厚度与耶鲁-布朗强迫症量表的强迫分项评分以及与贝克抑郁量表score.Conclusions：研究结果证实和扩展以前的报告表明，强迫症与形态学改变。ACC区域中最强大的皮质变薄的位置与先前报道的静息状态和认知任务执行期间功能改变的地形相匹配。(C)2012爱思唯尔有限公司保留所有权利。
Introduction: Obsessive-compulsive disorder (OCD) is characterized by a pattern of repetitive, intrusive thoughts and behaviours that patients do not want to but feel they have to perform. Functional brain imaging revealed dysfunctional pathways in OCD involving the anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia. Structural alterations in OCD have been discussed but analysis tools focussing on specific morphometric aspects such as cortical thickness have rarely been employed.Methods: We acquired MRI scans from 101 OCD patients and 95 healthy control subjects. FreeSurfer analysis software was employed to model the individual grey-white and pial surfaces to compute cortical thickness as our target measure.Results: Relative to controls, OCD patients demonstrate cortical thinning in dorsal and subgenual ACC (false discovery rate corrected at p < .001), as well as in several other regions within the fronto-parietal network (false discovery rate corrected at p < .05). Cortical thickness could not be predicted in whole brain analyses from symptom state, but there was a modest correlation of left dorsal ACC thickness with the obsession subscore of the Yale-Brown Obsessive-Compulsive Scale as well as with the Beck Depression Inventory score.Conclusions: The findings confirm and extend previous reports showing that OCD is associated with morphometric alterations. The location of the most robust cortical thinning in ACC regions matches the previously reported topography of functional alterations at resting state and during cognitive task execution. (C) 2012 Elsevier Ltd. All rights reserved.