Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
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DOI：
10.1002/bies.10195
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发表时间：
2003-01-01
期刊：
影响因子：
4
通讯作者：
Pfrieger, FW
中科院分区：
文献类型：
--
作者：
Pfrieger, FW
大脑的功能依赖于高度专业化的细胞之间的合作。神经元产生电信号，神经胶质细胞提供结构和代谢支持。在这里，我提出了一种新的神经元和星形胶质细胞之间的工作分担方式。最近对啮齿动物中枢神经系统(CNS)高纯度神经元原代培养的研究表明，在发育过程中，神经元减少甚至放弃胆固醇合成以节省能量，并通过脂蛋白从星形胶质细胞输入胆固醇。胆固醇穿梭可能被限制在远离胞体的隔室，包括突触，并可能受到电活动的调节。验证这些假说将有助于改善我们对大脑胆固醇代谢及其在神经退行性变中的作用的了解。
Brain function depends on the cooperation between highly specialized cells. Neurons generate electrical signals and glial cells provide structural and metabolic support. Here, I propose a new kind of job-sharing between neurons and astrocytes. Recent studies on primary cultures of highly purified neurons from the rodent central nervous system (CNS) suggest that, during development, neurons reduce or even abandon cholesterol synthesis to save energy and import cholesterol from astrocytes via lipoproteins. The cholesterol shuttle may be restricted to compartments distant from the soma including synapses and may be regulated by electrical activity. Testing these hypotheses will help to improve our still insufficient understanding of brain cholesterol metabolism and its role in neurodegeneration.