Induction of inducible heme oxygenase (HO-1) in the central nervous system: Is HO-1 helpful or harmful?
Induction of inducible heme oxygenase (HO-1) in the central nervous system: Is HO-1 helpful or harmful?
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DOI：
10.1007/bf03033275
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发表时间：
1999-06-01
影响因子：
3.7
通讯作者：
Kitamura, Yoshihisa
中科院分区：
文献类型：
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作者：
Matsuoka, Yasuji;Okazaki, Mitsuhiro;Kitamura, Yoshihisa
血红素加氧酶（HO）产生胆绿素和胆红素，这是强大的抗氧化剂，因此，它被认为是有助于对抗氧化应激。相比之下，HO也产生铁，如果处理不当，它可能会增加氧化应激。阐明HO的作用，即，为探讨HO-1的作用机制，本研究观察了大鼠短暂性前脑缺血后海马HO-1的表达、定位及其诱导机制。缺血后，HO-1的表达观察到早期，但短暂的CA 1锥体神经元和后来，但连续的胶质细胞。此外，HO-1表达的锥体神经元共定位以及磷酸化的c-Jun，这是一个关键步骤，在神经元凋亡。注射KA后，HO-1仅在胶质细胞中表达，而在神经元中不表达，并且HO-1主要在阿米巴样小胶质细胞中表达，沿着少量星形胶质细胞。HO-1表达阿米巴样小胶质细胞表达主要组织相容性复合物II类抗原，表明强激活。这些结果表明，HO-1可能具有双刃效应，其作用可能取决于细胞类型。这篇简短的综述旨在强调HO-1在神经退行性变中的作用。
Heme oxygenase (HO) produced biliverdin and bilirubin, which are powerful antioxidants, therefore, it has been proposed as helpful against oxidative stress. In contrast, HO also produces iron, and it could increase oxidative stress if not handled properly. To clarify the effect of HO, i.e., helpful or harmful, we examined the expression, localization, and induction mechanism of HO-1 in the rat hippocampus after transient forebrain ischemia and injection of kainic acid (KA). Following ischemia, HO-1 expression was observed early but transiently in the CA1 pyramidal neurons and later but continuously in glial cells. In addition, HO-1 expressing pyramidal neurons were colocalized well with phosphorylated c-Jun, which is a critical step in neuronal apoptosis. After injection of KA, HO-1 expression was observed only in glial cells but not neurons, and HO-1 expression was observed in predominantly ameboid microglia, along with a few astrocytes. HO-1 expressing ameboid microglia expressed major histocompatibility complex class II antigen, suggesting strong activation. These results suggested that HO-1 may have double-edged effects, and its effects may depend on the cell type. This short review is intended to highlight on the effect of HO-1 in neurodegeneration.