Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population.
Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population.
复制标题
一般人群中高血压、心房性心脏病和死亡率之间的关系。
DOI：
10.1093/ajh/hpac087
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发表时间：
2023
影响因子：
3.2
通讯作者：
Soliman,ElsayedZ
中科院分区：
文献类型：
--
作者：
ImtiazAhmad,Muhammad;Mendys,PhilM;Kelly,ScottP;Chen,LinY;Soliman,ElsayedZ
BACKGROUNDAtrial cardiopathy is associated with an increased risk of mortality. However, it is unclear whether this association is modified by hypertension, a risk factor for both atrial cardiopathy and mortality.MethodsThis analysis included 8,023 participants from the Third National Health and Nutrition Examination Survey. Electrocardiographic deep terminal negativity of P-wave in V1 ≥100 µV defined atrial cardiopathy. National Death Index was used to identify the date and cause of death. Cox proportional hazard analysis was used to examine the association of atrial cardiopathy with mortality among participants stratified by hypertension status.RESULTSIn total 2.7% of the participants had atrial cardiopathy. Over a median follow-up of 14 years, 2,922 all-cause deaths occurred, of which 1,058 were CVD. All-cause death rates were almost double among participants with concomitant atrial cardiopathy and elevated blood pressure (BP) (120–129/<80), stage 1 (130–139/80–89), or stage 2 hypertension (≥140/≥90) compared to their counterparts in the same hypertension stages without atrial cardiopathy (47.8, 61.3, and 80.2 vs. 23, 24.7, and 44.8 per 1,000 person-years (PY), respectively). In multivariable-adjusted models, a stronger association between atrial cardiopathy and all-cause mortality was observed in the presence compared to the absence of hypertension (HR (95% CI): 1.59 (1.25–2.01) vs. 0.67 (0.41–1.10), respectively, interactionP-value = 0.009). Similarly, an association between atrial cardiopathy and cardiovascular disease (CVD) mortality was observed in the presence compared to the absence of hypertension (HR (95% CI): 1.64 (1.08–2.47) vs. 0.63 (0.20–2.00), respectively, interactionP-value = 0.20).CONCLUSIONSConcomitant presence of high BP and atrial cardiopathy carries a higher risk of mortality, and the risk increases with higher BP levels.
