Further Exploration of Treatment Response in Latinos with Comorbid Asthma and Panic Disorder: A Brief Report of HRV and ETCO2 as Potential Mediators of Treatment Response.
Further Exploration of Treatment Response in Latinos with Comorbid Asthma and Panic Disorder: A Brief Report of HRV and ETCO2 as Potential Mediators of Treatment Response.
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进一步探索患有哮喘和恐慌症共病的拉丁裔患者的治疗反应：HRV 和 ETCO2 作为治疗反应潜在调节因素的简要报告。
DOI：
10.1007/s10484-020-09454-3
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发表时间：
2020
影响因子：
3
通讯作者：
Feldman,JonathanM
中科院分区：
文献类型：
--
作者：
Nelson,KristaL;Lu,Shou-En;Oken,Tanya;Lehrer,PaulM;Feldman,JonathanM
心率变异性（HRV）和潮气末二氧化碳（ETCO 2）与治疗反应的关系尚未在拉丁美洲人群或哮喘和惊恐障碍（PD）共病患者中进行研究。作为先前发表的研究的延伸，目前的研究探讨了心理生理变量作为治疗反应的可能介质。布朗克斯的拉丁裔哮喘-PD治疗完成者（N = 32）接受认知行为心理生理治疗（CBPT）或音乐放松治疗（MRT）。CBPT包括心率变异性生物反馈（HRVB）;即时心率数据可帮助个人学会影响自己的心率。样本主要是女性（93.8%）和波多黎各人（81.25%）。治疗组在人口统计学上没有差异，除了CBPT中的教育较少。惊恐障碍严重程度量表（PDSS）和哮喘控制问卷（ACQ）评估症状的变化。在8次治疗中的4次测量HRV和ETCO 2。基线ETCO 2和从第一次到最后一次心理生理学会议的HRV变化作为ACQ和PDSS变化的中介进行了研究。混合模型分析表明，在CPBT组，哮喘控制和PD严重程度的变化不介导的HRV的变化。在CBPT和MRT合并组中，PD严重程度的变化不受基线ETCO 2介导。这些发现可能是由于CBPT中HRVB的短暂性、多种治疗成分、ETCO 2不直接靶向和/或拉丁美洲哮喘PD患者的独特生理途径。
Heart rate variability (HRV) and end tidal CO2 (ETCO2) in relation to treatment response have not been studied in Latino populations or in comorbid asthma and panic disorder (PD). An extension of previously published research, the current study explored psychophysiological variables as possible mediators of treatment response. Latino treatment completers (N = 32) in the Bronx with asthma-PD received either Cognitive-Behavioral Psychophysiological Therapy (CBPT) or Music Relaxation Therapy (MRT). CBPT included HRV-biofeedback (HRVB); in-the-moment heart rate data to help an individual learn to influence his/her own heart rate. The sample was primarily female (93.8%) and Puerto Rican (81.25%). Treatment groups did not differ on demographics, except for less education in CBPT. The Panic Disorder Severity Scale (PDSS) and Asthma Control Questionnaire (ACQ) assessed changes in symptoms. HRV and ETCO2 were measured at four of eight therapy sessions. Baseline ETCO2 and changes in HRV from first to last of psychophysiology sessions were investigated as mediators of change on ACQ and PDSS. Mixed model analyses indicated in the CPBT group, changes in both asthma control and PD severity were not mediated by changes in HRV. In the CBPT and MRT groups combined, changes in PD severity were not mediated by baseline ETCO2. These findings may be due to the brevity of HRVB in CBPT, multiple treatment components, ETCO2 not directly targeted, and/or unique physiological pathways in Latinos with asthma-PD.