Tracking Single Particles Using Surface Plasmon Leakage Radiation Speckle
Tracking Single Particles Using Surface Plasmon Leakage Radiation Speckle
复制标题
使用表面等离子体泄漏辐射散斑跟踪单个粒子
DOI：
10.1109/jlt.2020.3035820
复制
发表时间：
2020-08
影响因子：
4.7
通讯作者：
J. Berk;C. Paterson;M. Foreman
中科院分区：
文献类型：
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作者：
J. Berk;C. Paterson;M. Foreman
小的生物颗粒如蛋白质或病毒的无标记跟踪在生物过程的研究中具有很大的实用性，然而，这种实验经常受到弱信号强度和对散射杂质的敏感性的阻碍。为了克服这些问题，我们在这里提出了一种新的技术，利用增强的灵敏度的干涉检测和表面等离子体激元的强场限制。具体而言，我们表明，由分析物颗粒和散斑参考场，来自随机散射的表面等离子体激元在粗糙的金属膜上传播的散射场之间的干扰，使粒子跟踪与亚波长精度。我们提出了我们的技术的分析框架，并通过蒙特卡罗模拟验证其对噪声的鲁棒性。
Label free tracking of small bio-particles such as proteins or viruses is of great utility in the study of biological processes, however such experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose a novel technique leveraging the enhanced sensitivity of both interferometric detection and the strong field confinement of surface plasmons. Specifically, we show that interference between the field scattered by an analyte particle and a speckle reference field, derived from random scattering of surface plasmons propagating on a rough metal film, enables particle tracking with sub-wavelength accuracy. We present the analytic framework of our technique and verify its robustness to noise through Monte Carlo simulations.