Stopping the Clock: Neobiosis As a Predecessor of Mammalian Hibernation and Possible Key to the Abolition of Aging
Stopping the Clock: Neobiosis As a Predecessor of Mammalian Hibernation and Possible Key to the Abolition of Aging
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DOI：
10.1089/rej.2009.0939
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发表时间：
2010-04-01
影响因子：
2.6
通讯作者：
Golub, Valeriy
中科院分区：
文献类型：
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作者：
Golub, Valeriy
许多哺乳动物在其一生中经历冬眠。冬眠前发生的温热状态的特征是细胞增殖受到抑制，应激反应降低，新陈代谢下降，免疫系统发生变化(季节性胸腺退化)。对进入恒温状态的幼年红田鼠(Cleereonomys Glreolus)、普通地鼠(Sorex Araneus)和肥胖睡鼠(Glis Glis)的数据分析表明，它们具有典型的两相生长，其延迟可能因周期而异。一种可逆性生长停止的生物学机制有效地“停止了这些动物的时钟”。人们怀疑这种机制是由生长激素、促甲状腺激素和褪黑素被抑制的生长抑素合成增加以及下丘脑视交叉上核的昼夜节律功能丧失所触发的。
A number of mammals undergo hibernation during their lifespan. The euthermal condition that occurs prior to hibernation is characterized by inhibition of cellular proliferation, reduction of stress reactivity, a decrease in metabolism, and changes in the immune system (seasonal thymus involution). Analysis of data of young red voles (Clethrionomys glareolus), common shrews (Sorex araneus), and fat dormice (Glis glis) while entering into the euthermal condition shows characteristic biphasic growth with a delay that can vary in its periods. A biological mechanism for reversible growth arrest effectively "stops the clock'' of these animals. It is suspected that this mechanism is triggered by an increase in somatostatin synthesis with inhibition of growth hormone, thyroid-stimulating hormone, and melatonin, and with a loss of circadian function in the suprachiasmatic nuclei of the hypothalamus.