Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels
Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels
复制标题
二级结构控制的多肽交联聚合水凝胶
DOI：
10.1021/acs.chemmater.9b04160
复制
发表时间：
2020-02-11
影响因子：
8.6
通讯作者：
Liu, Qiao
中科院分区：
文献类型：
--
作者：
Chen, Chongyi;Lan, Jun;Liu, Qiao
通过对多肽二级结构的调节，产生了一系列具有优异力学性能的天然多肽软质材料。在这里，我们讨论关于定制多肽的二级结构如何控制聚合物水凝胶的机械性能的详细见解。为此，我们开发了一系列由聚(3-丙基丙烯酸酯-谷氨酰胺)交联的具有可定制的二级结构-α-螺旋和无规卷曲的聚合物水凝胶。有趣的是，由α-螺旋交联剂交联的水凝胶显示出高的拉伸强度和韧性，这是因为沿着多肽主干的分子内氢键是协同的。此外，由于可逆的协作氢键，α-螺旋赋予了水凝胶高弹性和快速恢复的能力。相反，由无规卷曲交联剂交联的水凝胶显示出较差的拉伸强度和韧性。我们的研究在聚合物水凝胶中建立了定量的纳米尺度和宏观尺度的结构性质关系，对于利用具有特定二级结构的多肽进行软材料的合理设计具有重要意义。
Modulation of the secondary structures of peptides gives rise to a range of natural peptide-based soft materials with outstanding mechanical properties. Here, we discuss detailed insights on how the secondary structure of tailor-made polypeptides governs the mechanical properties of polymeric hydrogels. To this end, we developed a series of polymeric hydrogels cross-linked by poly(3-propyl-acrylate-glutamine) with tailorable secondary structures-alpha-helices and random coils. Interestingly, the hydrogels cross-linked by the alpha-helical cross-linker exhibit a high tensile strength and toughness because of the cooperative intramolecular hydrogen bonding along the polypeptide backbone. Furthermore, the alpha-helices endow the hydrogels with high resilience and rapid recovery because of their reversible cooperative hydrogen bonding. In contrast, the hydrogels cross-linked by the random coil cross-linker show inferior tensile strength and toughness. Our study establishes quantitative nanoscale/macroscale structure property relationships in polymeric hydrogels and has important implications for the rational design of soft materials using polypeptides with a specific secondary structure.