Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.
Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit.
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DOI：
10.1055/s-0036-1592109
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发表时间：
2016-12
影响因子：
2.7
通讯作者：
Kimberly WT
中科院分区：
文献类型：
--
作者：
Shah S;Kimberly WT
脑肿胀是临床急需解决的问题，常伴有缺血性卒中、脑出血和创伤性脑损伤，并增加与之相关的发病率和死亡率。它的发生是由于膜转运体和血脑屏障(BBB)的失效，导致细胞毒性、离子性和血管源性水肿。目前，去骨瓣减压术和渗透疗法是治疗的主要方法，但这些疗法并不能阻止导致脑肿胀的潜在分子级联反应。在脑水肿的分子基础上的最新进展为更新的靶向治疗选择打开了可能性。在这里，我们概述了目前快速诊断和干预的方法，以减少与脑肿胀相关的死亡率和发病率。
Brain swelling is an urgent clinical problem that frequently accompanies ischemic stroke, brain hemorrhage and traumatic brain injury, and it increases morbidity and mortality associated with them. It occurs due to failure of membrane transporters and the blood-brain barrier (BBB), resulting in combination of cytotoxic, ionic and vasogenic edema. Currently, decompressive craniectomy and osmotherapy are the mainstays of management, but these therapies do not halt the underlying molecular cascade leading to brain swelling. Recent advances in the molecular underpinnings of cerebral edema have opened up possibilities of newer targeted therapeutic options. Here we outline the current approach for rapid diagnosis and intervention to reduce mortality and morbidity associated with brain swelling.