STIM1/Orai1, ICRAC, and endothelial SOC.
STIM1/Orai1, ICRAC, and endothelial SOC.
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STIM1/Orai1、ICRAC 和内皮 SOC。
DOI：
10.1161/circresaha.109.196105
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发表时间：
2009
影响因子：
20.1
通讯作者：
Trebak,Mohamed
中科院分区：
文献类型：
--
作者：
Trebak,Mohamed
钙库操纵的钙（Ca 2）进入（SOCE）是一种进化上保守的调节Ca 2进入细胞的途径，其中来自内部钙库的Ca 2的耗尽发出质膜SOC通道激活的信号。1，2非选择性经典瞬时受体电位通道（TRPC）蛋白是哺乳动物SOC通道的潜在成分。然而，由此产生的文献没有提供研究者之间的共识，和编码SOC的TRPC的作用仍然是一个有争议的问题。2在我们最近的研究中，3我们通过显示由STIM 1和Orai 1独立于TRPC 1和TRPC 4编码的ECs中的ICRAC的证据，挑战了TRPC在内皮细胞（EC）SOCE中的作用。在给Circulation Research的一封信中，4 Beech指出了以前发表的数据与我们的数据之间的差异，并争辩说：（1）“尽管ICRAC记录的生物物理性质是无二价的，
Store-operated calcium (Ca2) entry (SOCE) is an evolutionarily conserved pathway of regulated Ca2 entry into cells whereby the depletion of Ca2 from internal stores signals the activation of plasma membrane SOC channels. 1, 2 Nonselective canonical transient receptor potential channel (TRPC) proteins were investigated as potential components of SOC channels in mammals. However, the resulting literature offer no consensus among investigators, and the role of TRPCs in encoding SOC remains a contentious issue. 2 In our recent study, 3 we challenged the role of TRPCs in endothelial cell (EC) SOCE by showing evidence for ICRAC in ECs encoded by STIM1 and Orai1 independently of TRPC1 and TRPC4. In a letter to Circulation Research, 4 Beech pointed out the discrepancies between previously published data and ours and contended:(1)“that although the biophysical properties of the ICRAC recorded in divalent-free