fMRI BOLD response of high-risk college students (Part 2): during memory priming of alcohol, marijuana and polydrug picture cues.
fMRI BOLD response of high-risk college students (Part 2): during memory priming of alcohol, marijuana and polydrug picture cues.
复制标题
高风险大学生的功能磁共振成像大胆反应（第 2 部分）：在酒精、大麻和多种药物图片线索的记忆启动过程中。
DOI：
10.1093/alcalc/agq043
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Bates,MarshaE
中科院分区：
文献类型：
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作者：
Ray,Suchismita;Hanson,Catherine;Hanson,StephenJ;Rahman,RifaquatM;Bates,MarshaE
目的：本研究采用功能性磁共振成像（fMRI）和反应时（RT）检测了在涉及酒精、多种药物、大麻和情绪图片线索的内隐重复启动记忆任务期间的大脑活动。方法：参与者是刚刚参加线索暴露研究的5名男性和5名女性高危大学生（Rayet等人，本期）。fMRI和RT数据收集，而参与者作出决定，以前看到的和新的图片cues.Results：行为RT和脑成像数据显示强大的记忆启动药物和酒精的线索。在神经学上，酒精刺激在左侧前额叶、双侧枕叶、双侧枕颞叶、右侧前额叶和右侧楔前叶均存在重复启动效应（Z范围为3.03 ~ 3.31P< 0.05）。多种药物线索在枕叶和颞叶区域引起启动，大麻线索在枕叶区域引起启动。结论：前额叶和岛叶皮质参与对酒精线索的反应（Rayet等人，这一问题）和随后的内隐记忆处理这些线索，在这项研究中发现，表明他们在维持高风险酒精使用行为的潜在作用。
Aims: This study examined brain activity using functional magnetic resonance imaging (fMRI) and reaction time (RT) during an implicit repetition priming memory task involving alcohol, polydrug, marijuana and emotional picture cues.Methods:Participants were 5 male and 5 female high-risk college students who had just participated in a cue exposure study (Rayet al., this issue). fMRI and RT data were collected while participants made decisions about previously seen and new picture cues.Results:Both behavioral RT and brain imaging data revealed strong memory priming for drug and alcohol cues. Neurologically, a repetition priming effect (suppression in neural activity for repeated cues) was observed in response to alcohol cues in the left prefrontal, bilateral occipital, and bilateral occipitotemporal regions, as well as right insula and right precuneus (Zranged from 3.03 to 3.31P< 0.05). Polydrug cues elicited priming in the occipital and temporal areas, and marijuana cues in the occipital area.Conclusions:Prefrontal and insular cortex involvement both in reactivity to alcohol cues (Rayet al., this issue) and subsequent implicit memory processing of these cues, as found in this study, suggests their potential role in the maintenance of high-risk alcohol use behaviors.