Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export
Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export
复制标题
炎症应激通过破坏细胞胆固醇输出而加剧肝脏胆固醇积累
DOI：
10.1111/j.1440-1746.2011.06986.x
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发表时间：
2012-05-01
影响因子：
4.1
通讯作者：
Ruan, Xiong Z.
中科院分区：
文献类型：
--
作者：
Chen, Yuyang;Chen, Yao;Ruan, Xiong Z.
背景和目的：炎症和胆固醇蓄积在非酒精性脂肪性肝病的发生发展中起重要作用。本研究旨在探讨炎症是否通过破坏肝脏胆固醇输出而加重胆固醇蓄积，并探讨其潜在机制。
Background and Aim: Both inflammation and cholesterol accumulation play important roles in the development of non-alcoholic fatty liver disease. This study was undertaken to investigate whether inflammation aggravated cholesterol accumulation via disrupting hepatic cholesterol export and we explored the underlying mechanisms.