An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
复制标题
DOI：
10.1126/science.1107573
复制
发表时间：
2005-04-15
期刊：
影响因子：
56.9
通讯作者：
McGinnis, W
中科院分区：
文献类型：
--
作者：
Mace, KA;Pearson, JC;McGinnis, W
我们使用受伤的果蝇胚胎来定义一个进化上保守的修复表皮表面屏障的途径。该途径包括来自Ddc基因的伤口反应增强子，其需要颗粒状头（grh）功能和Grh转录因子的结合位点。在信号传导水平，酪氨酸激酶和细胞外信号调节激酶（ERK）的活性诱导表皮细胞附近的伤口，激活的ERK是需要一个强大的伤口反应。这种依赖GRH的途径的保护表明，昆虫表皮和哺乳动物皮肤的修复是由一个古老的，共享的控制系统，用于构建和加热动物体表屏障。
We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and heating the animal body surface barrier.