Drug targets in mycobacterial sulfur metabolism.
Drug targets in mycobacterial sulfur metabolism.
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DOI：
10.2174/187152607781001772
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发表时间：
2007-05
期刊：
影响因子：
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通讯作者：
Devayani P. Bhave;W. Muse;Kate S. Carroll
中科院分区：
文献类型：
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作者：
Devayani P. Bhave;W. Muse;Kate S. Carroll
目前迫切需要发现新的抗菌作用靶点，以解决耐多药和潜伏性结核病感染的问题。硫代谢途径对于许多致病菌（包括结核分枝杆菌）的生存和毒力表达至关重要。此外，微生物硫代谢途径在人类中基本上不存在，因此代表了治疗干预的独特靶点。在这篇综述中，我们总结了我们目前的了解与生产相关的酶的硫酸化和还原含硫代谢产物在分枝杆菌。这些催化剂的小分子抑制剂代表了有价值的化学工具，可用于研究硫代谢在整个分枝杆菌生命周期中的作用，也可能代表药物开发的新线索。在此基础上，对硫代谢酶抑制剂的研究进展进行了综述。
The identification of new antibacterial targets is urgently needed to address multidrug resistant and latent tuberculosis infection. Sulfur metabolic pathways are essential for survival and the expression of virulence in many pathogenic bacteria, including Mycobacterium tuberculosis. In addition, microbial sulfur metabolic pathways are largely absent in humans and therefore, represent unique targets for therapeutic intervention. In this review, we summarize our current understanding of the enzymes associated with the production of sulfated and reduced sulfur-containing metabolites in Mycobacteria. Small molecule inhibitors of these catalysts represent valuable chemical tools that can be used to investigate the role of sulfur metabolism throughout the Mycobacterial lifecycle and may also represent new leads for drug development. In this light, we also summarize recent progress in the development of inhibitors of sulfur metabolism enzymes.