In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia.
In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia.
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DOI：
10.1038/s41537-022-00293-1
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发表时间：
2022-10-26
期刊：
影响因子：
--
通讯作者：
Pantelis, Christos
中科院分区：
文献类型：
--
作者：
Ravanfar, Parsa;Syeda, Warda T.;Jayaram, Mahesh;Rushmore, R. Jarrett;Moffat, Bradford;Lin, Alexander P.;Lyall, Amanda E.;Merritt, Antonia H.;Yaghmaie, Negin;Laskaris, Liliana;Luza, Sandra;Opazo, Carlos M.;Liberg, Benny;Chakravarty, M. Mallar;Devenyi, Gabriel A.;Desmond, Patricia;Cropley, Vanessa L.;Makris, Nikos;Shenton, Martha E.;Bush, Ashley, I;Velakoulis, Dennis;Pantelis, Christos
脑铁是多巴胺能神经传递的中枢，多巴胺能神经传递是精神分裂症病理中的关键成分。铁还会产生氧化应激，这是精神分裂症患者灰质体积减少的一种机制。脑铁在精神分裂症中的作用及其与氧化应激的潜在联系以前还没有被研究过。在这项研究中，我们对12例慢性精神分裂症患者和14例年龄匹配的健康对照组进行了7-TESLA磁共振定量易感地形图(QSM)、磁共振波谱(MRS)和结构T1成像。精神分裂症患者双侧壳核QSM值较高，尾侧扣带回前部(CACC)磷酸肌酸和乳酸浓度较高。基于网络的跨皮质纹状体通路的QSM相关性分析，以及QSM、MRS和容量之间的相关性，显示了不同组之间的明显模式。这项研究介绍了精神分裂症患者壳核中铁的增加，以及整个网络中铁和代谢状态的紊乱。
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in schizophrenia. The role of brain iron in schizophrenia and its potential link to oxidative stress has not been previously examined. In this study, we used 7-Tesla MRI quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and structural T1 imaging in 12 individuals with chronic schizophrenia and 14 healthy age-matched controls. In schizophrenia, there were higher QSM values in bilateral putamen and higher concentrations of phosphocreatine and lactate in caudal anterior cingulate cortex (caCC). Network-based correlation analysis of QSM across corticostriatal pathways as well as the correlation between QSM, MRS, and volume, showed distinct patterns between groups. This study introduces increased iron in the putamen in schizophrenia in addition to network-wide disturbances of iron and metabolic status.
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影响因子：
4.4
作者：
Duarte JMN;Xin L
通讯作者：
Xin L
影响因子：
5.7
作者：
Hametner, Simon;Endmayr, Verena;Grabner, Guenther
通讯作者：
Grabner, Guenther
影响因子：
2.9
作者：
Frantom, PA;Seravalli, J;Fitzpatrick, PF
通讯作者：
Fitzpatrick, PF
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce