Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
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DOI：
10.2106/jbjs.g.01443
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发表时间：
2008-02-01
影响因子：
5.3
通讯作者：
Einhorn, Thomas A.
中科院分区：
文献类型：
--
作者：
Barnes, George L.;Kakar, Sanjeev;Einhorn, Thomas A.
在过去的几年中，人们对骨修复生物学和促进骨折愈合的潜在技术越来越感兴趣。这种兴趣部分源于人口年龄的增长以及人们认识到年龄的增长会增加骨折后并发症的风险。尽管局部植入或注射生长因子的使用受到了最多的关注，但用于增强骨修复的全身治疗，特别是对于骨修复可能减弱或延迟的情况，目前正在研究中。自从甲状旁腺激素 (PTH) 被批准作为骨质疏松症的合成代谢治疗药物以来，人们对该化合物在肌肉骨骼疾病中的其他潜在临床用途越来越感兴趣。现在人们普遍认为，PTH 给药是增加骨质疏松症患者骨密度和预防骨折的有效疗法。最近，越来越多的证据支持这样的结论：PTH 也将是一种有效的合成代谢疗法，可增强骨折后的骨修复。本综述重点介绍了最近的研究，证明了 PTH 在多种骨折模型中骨修复管理中的潜力，并重点介绍了正在进行的 PTH 对软骨内骨修复作用机制的研究。
Over the past several years, there has been an increasing interest in the biology of bone repair and potential technologies for enhancing fracture-healing. Part of this interest is derived from the growing age of the population and the recognition that increased age carries an increased risk of complications after fracture. Although use of locally implanted or injected growth factors has received the most attention, systemic treatments for the enhancement of bone repair, especially for situations in which bone repair may be diminished or delayed, are now under investigation. Since the approval of parathyroid hormone (PTH) as an anabolic treatment for osteoporosis, there has been an increasing interest in other potential clinical uses for this compound in musculoskeletal conditions. It is now widely recognized that PTH administration is an effective therapy to increase bone mineral density and prevent fractures in patients with osteoporosis. More recently, a growing body of evidence has supported the conclusion that PTH will also be an effective anabolic therapy for the enhancement of bone repair after fracture. This review focuses on the recent research demonstrating the potential of PTH in the management of bone repair in a number of fracture models and also highlights the ongoing studies into the mechanisms of PTH actions on endochondral bone repair.