ANTIPROLIFERATIVE EFFECT AND SELECTIVITY OF SODIUM DICHLORO-BIS [N-PHENYL-5-CHLORO-SALICYLIDENEIMINATO-N, O] RUTHENATE (III) IN VITRO
ANTIPROLIFERATIVE EFFECT AND SELECTIVITY OF SODIUM DICHLORO-BIS [N-PHENYL-5-CHLORO-SALICYLIDENEIMINATO-N, O] RUTHENATE (III) IN VITRO
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二氯双[N-苯基-5-氯-水杨基亚胺基-N,O]钌酸钠(III)的体外抗增殖作用和选择性
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
S. K. Pavelić
中科院分区：
文献类型：
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作者：
E. Kahrović;S. K. Pavelić
近几十年来，钌配合物因其抗癌特性而引起了人们的特别关注。由于许多含有希夫碱的钌（III）配合物对DNA的结合表现出中等的活性，因此我们测试了含有两个O， n -双齿希夫碱的氯钌（III）配合物对宫颈癌、胰腺癌、肝细胞癌、结直肠腺癌转移病变和非肿瘤细胞WI38的抗增殖作用。该复合物在体外表现出适度的抗增殖特性，对结肠癌SW620转移灶具有显著的选择性。基于对钌基抗癌药物的阳性研究，以及与正在使用的铂类药物相比，钌基抗癌药物的体外细胞毒性（IC 50）普遍较低，该化合物可能是体内研究的候选化合物，特别是对SW620。
Ruthenium complexes attracted special attention in recent decades due to their anticancer properties. Since a number of Ru(III) complexes with Schiff bases showed moderate activity to bind DNA, antiproliferative effect of a chloro-ruthenium(III) complex which contains two O,N-bidentate Schiff bases derived from 5-chloro-salicylaldehyde was tested against cervical carcinoma, pancreatic carcinoma, hepatocellular carcinoma, metastatic lesions of colorectal adenocarcinoma and nontumoral cells WI38. The complex showed moderate antiproliferative properties in vitro and significant selectivity to SW620 metastatic lesions of colon cancer. Based on the positive research on ruthenium-based anticancer drugs and their generally moderate cytotoxicity in vitro (IC 50 ) compared to platinum drugs which are in use, the titled compound might be a candidate for investigation in vivo , particularly to SW620.
影响因子：
11.2
作者：
Zhang, Shuzhong;Lovejoy, Katherine S.;Giacomini, Kathleen M.
通讯作者：
Giacomini, Kathleen M.