Specific stimulation of human T lymphocytes by substance P.
Specific stimulation of human T lymphocytes by substance P.
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DOI：
10.4049/jimmunol.131.4.1613
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发表时间：
1983-10
影响因子：
4.4
通讯作者：
D. Payan;D. Brewster;E. Goetzl
中科院分区：
文献类型：
--
作者：
D. Payan;D. Brewster;E. Goetzl
通过[3H]胸苷和[3H]亮氨酸的摄取评估，物质P（SP）和SP（4-11）在各自浓度10（-11）M至10（-7）M和10（-9）M至10（-7）M下显着刺激体外人T淋巴细胞的增殖。 10(-9)M至10(-8)M SP和10(-10)M至10(-7)M SP(4-11)增强了人T淋巴细胞对PHA的增殖反应。无活性类似物[D-Pro2、D-Phe7、D-Trp9]-SP 抑制 SP 对 T 淋巴细胞的作用。 SP 对 T 淋巴细胞的特异性刺激表明了周围神经源性因子调节免疫反应的独特机制。
Substance P (SP) and SP(4-11) stimulated significantly the proliferation of human T lymphocytes in vitro at respective concentrations of 10(-11) M to 10(-7) M and 10(-9) M to 10(-7) M, as assessed by the uptake of [3H]thymidine and [3H]leucine. The proliferative response of human T lymphocytes to PHA was augmented by 10(-9) M to 10(-8) M SP and 10(-10) M to 10(-7) M SP(4-11). The inactive analogue [D-Pro2, D-Phe7, D-Trp9]-SP inhibited the effects of SP on T lymphocytes. The specific stimulation of T lymphocytes by SP suggests a unique mechanism for the regulation of immunologic responses by peripheral nerve-derived factors.