Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.
Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.
复制标题
DOI：
10.1016/j.jhep.2010.05.003
复制
发表时间：
2010-09
影响因子：
25.7
通讯作者：
Thorgeirsson SS
中科院分区：
文献类型：
--
作者：
Marquardt JU;Factor VM;Thorgeirsson SS
两种主要的癌症发生模型假设肿瘤的随机（克隆进化）或等级组织（癌症干细胞模型）。根据后者，肿瘤进化的生发中心是一种癌症干细胞（CSC），它与正常的成体干细胞相似，具有自我更新的能力和分化潜能。在过去的几年中，出现了令人信服的证据，支持许多实体肿瘤（包括肝细胞癌）的分层癌症模型。CSCs被认为不仅对肿瘤的起始负责，而且对远处转移和治疗后复发的产生负责。这些特征与人类肝细胞癌等多重耐药肿瘤实体特别相关，可能预示着这种致命疾病管理模式的转变。因此，肝脏csc的鉴定和详细表征对于改进预防方法、加强早期发现和扩大有限的治疗选择至关重要。尽管目前在了解CSCs对肿瘤异质性产生的贡献方面取得了进展，但对CSCs的分子复杂性和确切调控知之甚少。本文综述了肝干细胞独特特性的遗传和表观遗传调控机制，重点阐述了肝干细胞的关键调控途径及其临床意义。
The two dominant models of carcinogenesis postulate stochastic (clonal evolution) or hierarchic organization of tumor (cancer stem cell model). According to the latter, at the germinal center of tumor evolution is a cancer stem cell (CSC) which, similar to normal adult stem cells, possesses the capacity of self-renewal and a differentiation potential. Over the past few years, compelling evidence has emerged in support of the hierarchic cancer model for many solid tumors including hepatocellular cancers. The CSCs are posited to be responsible not only for tumor initiation but also for the generation of distant metastasis and relapse after therapy. These characteristics are particularly relevant for a multi-resistant tumor entity like human hepatocellular carcinoma and may herald a paradigm shift in the management of this deadly disease. Identification and detailed characterization of liver CSCs is therefore imperative for improving prevention approaches, enhancing early detection, and extending the limited treatment options. Despite the current progress in understanding the contribution of CSCs to the generation of heterogeneity of tumors, the molecular complexity and exact regulation of CSCs is poorly understood. This review focuses on the genetic and epigenetic mechanisms that regulate and define the unique CSC properties with an emphasis on key regulatory pathways of liver CSCs and their clinical significance.
登录
查看更多内容
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
11.2
作者：
Chiba, Tetsuhiro;Miyagi, Satoru;Iwama, Atsushi
通讯作者：
Iwama, Atsushi
影响因子：
30.8
作者：
Broeske, Ann-Marie;Vockentanz, Lena;Rosenbauer, Frank
通讯作者：
Rosenbauer, Frank
影响因子：
13.5
作者：
Boyault, Sandrine;Rickman, David S.;Zucman-Rossi, Jessica
通讯作者：
Zucman-Rossi, Jessica
影响因子：
29.4
作者：
Chiba, Tetsuhiro;Zheng, Yun-Wen;Taniguchi, Hideki
通讯作者：
Taniguchi, Hideki