Multisensory Mechanisms in Temporo-Parietal Cortex Support Self-Location and First-Person Perspective
Multisensory Mechanisms in Temporo-Parietal Cortex Support Self-Location and First-Person Perspective
复制标题
DOI：
10.1016/j.neuron.2011.03.009
复制
发表时间：
2011-04-28
期刊：
影响因子：
16.2
通讯作者：
Blanke, Olaf
中科院分区：
文献类型：
--
作者：
Ionta, Silvio;Heydrich, Lukas;Blanke, Olaf
自我意识主要是通过哲学探究而不是实证神经科学研究来研究的，这导致了过多的不同理论和缺乏数据驱动的理论。利用机器人技术，我们实现了特定的身体冲突，并通过改变健康受试者的自我定位（自我定位），在自我意识的一个基本方面引发了可预测的变化。功能性磁共振成像显示，颞顶交界处（TPJ）活动反映了自我定位的实验变化，这也取决于由于视觉-触觉和视觉-前庭冲突而导致的第一人称视角。此外，在一项针对具有明确的异常自定位状态的神经系统患者的大型病变分析研究中，脑损伤也定位于TPJ，这提供了TPJ编码自定位的因果证据。我们的研究结果表明，TPJ 的多感觉整合反映了人类最基本的主观感受之一：作为一个位于空间某个位置的实体并从这个位置和角度感知世界的感觉。
Self-consciousness has mostly been approached by philosophical enquiry and not by empirical neuroscientific study, leading to an overabundance of diverging theories and an absence of data-driven theories. Using robotic technology, we achieved specific bodily conflicts and induced predictable changes in a fundamental aspect of self-consciousness by altering where healthy subjects experienced themselves to be (self-location). Functional magnetic resonance imaging revealed that temporo-parietal junction (TPJ) activity reflected experimental changes in self-location that also depended on the first-person perspective due to visuo-tactile and visuo-vestibular conflicts. Moreover, in a large lesion analysis study of neurological patients with a well-defined state of abnormal self-location, brain damage was also localized at TPJ, providing causal evidence that TPJ encodes self-location. Our findings reveal that multisensory integration at the TPJ reflects one of the most fundamental subjective feelings of humans: the feeling of being an entity localized at a position in space and perceiving the world from this position and perspective.