Biodegradable poly(carbonate‐ether)s with thermoresponsive feature at body temperature
Biodegradable poly(carbonate‐ether)s with thermoresponsive feature at body temperature
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DOI：
10.1002/pola.26374
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发表时间：
2013-01
期刊：
影响因子：
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通讯作者：
Lin Gu;Yonggang Gao;Yusheng Qin;Xuesi Chen;Xianhong Wang;Fo-song Wang
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文献类型：
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作者：
Lin Gu;Yonggang Gao;Yusheng Qin;Xuesi Chen;Xianhong Wang;Fo-song Wang
以二氧化碳和环氧乙烷为原料，在双金属氰化物催化下，合成了具有较低体温临界溶解温度的新型可生物降解的聚碳酸酯-醚-S(PCEs)。PCEs的碳酸盐单元(CU)含量为1.042.4m ol%，相对分子质量为2.7247 kg/m ol，在去离子水中表现出可逆热响应性，在21.5-84.1℃范围内具有可逆热响应性。特别是，含26.0摩尔%铜的PCE水溶液的LCST约为36.1℃，非常接近体温。有趣的是，发现其相变行为随PCE浓度的变化而变化。对于Mn2.7 kg/mol，Cu30.0mol%的PCE，当PCE的浓度从10g/L增加到1g/L时，相变温度从21.5℃增加到36.7℃。动态光散射表明，相变可能是由线团向球状转变所致。具有热响应性的可生物降解的PCE在体温下具有LCST，在生物医学应用，特别是在体内应用方面具有广阔的前景。(C)2012 Wiley期刊公司J Polym Sci Part A：Polym Chem，2013
Novel biodegradable poly(carbonate-ether)s (PCEs) with lower critical solution temperature (LCST) at body temperature were synthesized by copolymerization of CO2 and ethylene oxide (EO) under double metal cyanide (DMC) catalyst. The PCEs showed carbonate unit (CU) content of 1.042.4 mol % and molecular weight of 2.7247 kg/mol, which exhibited reversible thermoresponsive feature in deionized water with LCST in a broad window from 21.5 to 84.1 degrees C. The LCST was highly sensitive to the CU content and the molecular weight of PCEs, and it showed a linear relation with CU content for PCEs with similar molecular weight. In particular, aqueous solution of PCE with a 26.0 mol % of CU showed an LCST around 36.1 degrees C, which was very close to the body temperature. Interestingly, it was found that the phase transition behavior changed with PCE concentration. For PCE with Mn of 2.7 kg/mol and CU content of 30.0 mol %, the LCST increased from 21.5 to 36.7 degrees C when the PCE concentration changed from 10 to 1 g/L. Dynamic light scattering indicated that the phase transition was possibly due to a coil-to-globule transition. The thermoresponsive biodegradable PCE with LCST at body temperature is promising for biomedical applications, especially for in vivo applications. (c) 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013