Diagnostic accuracy of microcomputed tomography for osseous abnormalities in the rat temporomandibular joint condyle
Diagnostic accuracy of microcomputed tomography for osseous abnormalities in the rat temporomandibular joint condyle
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DOI：
10.1259/dmfr/24350438
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发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Shirakawa, T.
中科院分区：
文献类型：
--
作者：
Kameoka, S.;Kuroki, Y.;Shirakawa, T.
目的：我们的目的是考察诊断的准确性吗？体内显微CT观察大鼠颞下颌关节（TMJ）髁突骨性异常，以宏观观察为“金标准”。方法：通过向大鼠一侧颞下颌关节腔内注射炎性完全弗氏佐剂（CFA）制备30个TMJ关节炎模型。然后使用显微 CT 对 TMJ 髁进行成像。对样本进行宏观评估，以确定骨异常情况，包括侵蚀、骨赘、扁平和凹陷。使用相同的标准独立评估显微 CT 图像的异常情况。使用显微CT设备使用显微XYZ技术产生三个平面的图像。结果：根据肉眼观察，60个大鼠髁突中有26个显示骨异常。显微 XYZ 图像检测到 25 个髁突异常。 Micro-CT诊断髁突的准确度为0.98，敏感性为0.96，特异性为1.0。结论：Micro-CT诊断效果良好。因此，它是评估大鼠颞下颌关节骨异常的有效技术。牙颌面放射学 (2009) 38, 465-469。 DOI：10.1259/dmfr/24350438
Objectives: Our aim was to investigate the diagnostic accuracy of it? vivo micro-CT for osseous abnormalities of the rat temporomandibular joint (TMJ) condyle, using macroscopic observations as the "gold standard".Methods: A 30 TMJ arthritis model was prepared by injecting inflammatory complete Freund's adjuvant (CFA) into one side of the TMJ cavities of rats. The TMJ condyles were then imaged using micro-CT. The samples were macroscopically evaluated for osseous abnormalities, including erosions, osteophytes, flattening and concavity. The micro-CT images were independently assessed for abnormalities using the same criteria. Images in three planes were produced using the micro-XYZ technique with the micro-CT equipment.Results: According to the macroscopic observations, 26 of the 60 rat condyles showed osseous abnormalities. The micro-XYZ images detected abnormalities in 25 of the condyles. The condyle diagnostic accuracy of micro-CT was 0.98, the sensitivity was 0.96 and the specificity was 1.0.Conclusions: Good diagnostic results were obtained using micro-CT. It is therefore an effective technique for the evaluation of osseous abnormalities in the rat TMJ condyle. Dentomaxillofacial Radiology (2009) 38, 465-469. doi: 10.1259/dmfr/24350438